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Arene ruthenium dithiolato–carborane complexes for boron neutron capture therapy (BNCT)
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Romero-Canelón, Isolda, Phoenix, Ben, Pitto-Barry, Anaïs, Tran, Johanna, Soldevila-Barreda, Joan J., Kirby, Nigel, Green, Stuart, Sadler, P. J. and Barry, Nicolas P. E. (2015) Arene ruthenium dithiolato–carborane complexes for boron neutron capture therapy (BNCT). Journal of organometallic chemistry, 796 . pp. 17-25. doi:10.1016/j.jorganchem.2015.05.011 ISSN 0022-328X.
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WRAP_1-s2.0-S0022328X15002818-main.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1730Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.jorganchem.2015.05.011
Abstract
We report the effect of low-energy thermal neutron irradiation on the antiproliferative activities of a highly hydrophobic organometallic arene ruthenium dithiolato–carborane complex [Ru(p-cymene) (1,2-dicarba-closo-dodecarborane-1,2-dithiolato)] (1), and of its formulation in Pluronic® triblock copolymer P123 core–shell micelles (RuMs). Complex 1 was highly active, with and without neutron irradiation, towards human ovarian cancer cells (A2780; IC50 0.14 μM and 0.17 μM, respectively) and cisplatin-resistant human ovarian cancer cells (A2780cisR; IC50 0.05 and 0.13 μM, respectively). Complex 1 was particularly sensitive to neutron irradiation in A2780cisR cells (2.6 × more potent after irradiation compared to non-irradiation). Although less potent, the encapsulated complex 1 as RuMs nanoparticles resulted in higher cellular accumulation (2.5×), and was sensitive to neutron irradiation in A2780 cells (1.4× more potent upon irradiation compared to non-irradiation).
| Item Type: | Journal Article | ||||||||||
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| Subjects: | Q Science > QD Chemistry | ||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||
| Library of Congress Subject Headings (LCSH): | Ruthenium compounds, Carboranes, Micelles, Ovaries -- Cancer -- Treatment -- Research | ||||||||||
| Journal or Publication Title: | Journal of organometallic chemistry | ||||||||||
| Publisher: | Elsevier S.A. | ||||||||||
| ISSN: | 0022-328X | ||||||||||
| Official Date: | 1 November 2015 | ||||||||||
| Dates: |
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| Volume: | 796 | ||||||||||
| Number of Pages: | 9 | ||||||||||
| Page Range: | pp. 17-25 | ||||||||||
| DOI: | 10.1016/j.jorganchem.2015.05.011 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
| Description: | Dedicated to Professor Georg Süss-Fink on the occasion of his 65th birthday |
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| Date of first compliant deposit: | 22 December 2015 | ||||||||||
| Date of first compliant Open Access: | 22 December 2015 | ||||||||||
| Funder: | Engineering and Physical Sciences Research Council (EPSRC), Leverhulme Trust (LT), University of Warwick, University of Birmingham, European Research Council (ERC) | ||||||||||
| Grant number: | ECF-2013-414 (LT), RD14102 (UoW), UOBFOF026 (UoB), 247450 (ERC), EP/F034210/1 (EPSRC) |
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