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Similarities of K-ATP(+) channel expression and Ca2+ changes in pancreatic beta cells and hypothalamic neurons
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UNSPECIFIED (2005) Similarities of K-ATP(+) channel expression and Ca2+ changes in pancreatic beta cells and hypothalamic neurons. PANCREAS, 30 (3). pp. 227-232. ISSN 0885-3177.
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Abstract
The mechanisms through which pancreatic beta cells recognize and respond to changes in circulating glucose are well understood. Evidence is accumulating that a subpopulation of neurons in the ventromedial hypothalamus (VMH) use similar cellular mechanisms to sense changes in extracellular glucose. In the present study, we used PCR and single-cell calcium imaging techniques to investigate whether glucose-sensing cells in the pancreas and hypothalamus employ a similar set of stimulus-response elements. Dispersed cells from mouse pancreata and hypothalamus were used in conjunction with the insulin-secreting cell line MIN6. We present functional data suggesting that both pancreatic and a subpopulation of hypothalamic cells exhibit glucose- and tolbutamide-evoked changes in cytosolic calcium and consider some clinical implications of different glucose sensors using the same mechanisms.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RC Internal medicine | ||||
Journal or Publication Title: | PANCREAS | ||||
Publisher: | LIPPINCOTT WILLIAMS & WILKINS | ||||
ISSN: | 0885-3177 | ||||
Official Date: | April 2005 | ||||
Dates: |
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Volume: | 30 | ||||
Number: | 3 | ||||
Number of Pages: | 6 | ||||
Page Range: | pp. 227-232 | ||||
Publication Status: | Published |
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