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Multicenter randomized trial of amnioinfusion
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Fraser, W., Marcoux, S., Prendiville, W., Petrou, Stavros, Hofmeyr, J., Reinharz, D., Goulet, C. and Ohlsson, A. (2000) Multicenter randomized trial of amnioinfusion. Journal de Gynecologie, Obstetrique et Biologie de la Reproduction , 29 (3). pp. 312-315. ISSN 0368-2315.
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Official URL: http://europepmc.org/abstract/MED/10804381
Abstract
Meconium staining of the amniotic fluid in labor is a frequent problem that is associated with an increase in the risk of neonatal and maternal morbidity. Amnioinfusion is a simple technique that is designed to prevent neonatal and maternal morbidity associated with meconium. Preliminary studies indicate that amnioinfusion is a promising approach to the prevention of such complications of labor. However, further research is required. The primary objective of this multi-centre randomized controlled study is to determine if amnioinfusion for thick meconium stained amniotic fluid results in a reduction in perinatal death or moderate to severe meconium aspiration syndrome. We will also assess the effects of amnioinfusion on other indicators of neonatal morbidity and on cesarean section. The study includes an evaluation of womens views on their childbirth experience and an economic evaluation of a policy of amnioinfusion The study will be achieved with the collaboration of approximately 50 obstetrical centres from across Canada, US, Europe, South America and South Africa. This multicentre trial will provide urgently needed information on the efficacy and effectiveness of amniofusion for the indication of meconium stained amniotic fluid.
| Item Type: | Journal Article | ||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Journal de Gynecologie, Obstetrique et Biologie de la Reproduction | ||||
| Publisher: | Elsevier Masson | ||||
| ISSN: | 0368-2315 | ||||
| Official Date: | 2000 | ||||
| Dates: |
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| Volume: | 29 | ||||
| Number: | 3 | ||||
| Page Range: | pp. 312-315 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Related URLs: |
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