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Graft-vs-tumor effect in patients with advanced nasopharyngeal cancer treated with nonmyeloablative allogeneic PBSC transplantation
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Toh, Han Chong, Chia, Whay Kuang, Sun, L., Thng, C. H., Soe, Y., Phoon, Y. P., Yap, Swee Peng, Lim, W. T., Tai, W. M., Hee, Siew Wan, Tan, S. H. (Seow-Hwei), Leong, S. S. and Tan, E. H. (2011) Graft-vs-tumor effect in patients with advanced nasopharyngeal cancer treated with nonmyeloablative allogeneic PBSC transplantation. Bone Marrow Transplantation, 46 (4). pp. 573-579. doi:10.1038/bmt.2010.161 ISSN 0268-3369 .
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Official URL: http://dx.doi.org/10.1038/bmt.2010.161
Abstract
While nonmyeloablative peripheral blood stem cell transplantation (NST) has shown efficacy against several solid tumors, it is untested in nasopharyngeal cancer (NPC). In a phase II clinical trial, 21 patients with pretreated metastatic NPC underwent NST with sibling PBSC allografts, using CY conditioning, thymic irradiation and in vivo T-cell depletion with thymoglobulin. Stable lymphohematopoietic chimerism was achieved in most patients and prophylactic CYA was tapered at a median of day +30. Seven patients (33%) showed partial response and three (14%) achieved stable disease. Four patients were alive at 2 years and three showed prolonged disease control of 344, 525 and 550 days. With a median follow-up of 209 (4–1147) days, the median PFS was 100 days (95% confidence interval (CI), 66–128 days), and median OS was 209 days (95% CI, 128–236 days). Patients with chronic GVHD had better survival—median OS 426 days (95% CI, 194–NE days) vs 143 days (95% CI, 114–226 days) (P=0.010). Thus, NST may induce meaningful clinical responses in patients with advanced NPC.
Item Type: | Journal Article | ||||
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Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Graft versus host disease, Cancer -- Treatment | ||||
Journal or Publication Title: | Bone Marrow Transplantation | ||||
Publisher: | Nature Publishing Group | ||||
ISSN: | 0268-3369 | ||||
Official Date: | 2011 | ||||
Dates: |
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Volume: | 46 | ||||
Number: | 4 | ||||
Number of Pages: | 7 | ||||
Page Range: | pp. 573-579 | ||||
DOI: | 10.1038/bmt.2010.161 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Reuse Statement (publisher, data, author rights): | Cited By :2 Export Date: 5 March 2015 | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 31 December 2015 | ||||
Date of first compliant Open Access: | 31 December 2015 | ||||
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