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A preliminary evaluation of the validity of at-risk criteria for bipolar disorders in help-seeking adolescents and young adults
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Bechdolf, Andreas, Nelson, Barnaby, Cotton, Sue M., Chanen, Andrew, Thompson, Andrew D., Kettle, Jonathan, Conus, Phillippe, Amminger, G. Paul, Yung, Alison R., Berk, Michael and McGorry, Patrick D. (2010) A preliminary evaluation of the validity of at-risk criteria for bipolar disorders in help-seeking adolescents and young adults. Journal of Affective Disorders, 127 (1-3). pp. 316-320. doi:10.1016/j.jad.2010.06.016 ISSN 0165-0327.
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Official URL: http://dx.doi.org/10.1016/j.jad.2010.06.016
Abstract
Introduction:
We have developed ultra-high risk criteria for bipolar affective disorder (bipolar at-risk — BAR) which include general criteria such as being in the peak age range of the onset of the disorder and a combination of specific criteria including sub-threshold mania, depressive symptoms, cyclothymic features and genetic risk. In the current study, the predictive validity of these criteria were tested in help-seeking adolescents and young adults.
Method:
This medical file-audit study was conducted at ORYGEN Youth Health (OYH), a public mental health program for young people aged between 15 and 24 years and living in metropolitan Melbourne, Australia. BAR criteria were applied to the intake assessments of all non-psychotic patients who were being treated in OYH on 31 January, 2008. All entries were then checked for conversion criteria. Hypomania/mania related additions or alterations to existing treatments or initiation of new treatment by the treating psychiatrist served as conversion criteria to mania.
Results:
The BAR criteria were applied to 173 intake assessments. Of these, 22 patients (12.7%) met BAR criteria. The follow-up period of the sample was 265.5 days on average (SD 214.7). There were significantly more cases in the BAR group (22.7%, n=5) than in the non-BAR group (0.7%, n=1) who met conversion criteria (p<.001).
Conclusions:
These findings support the notion that people who develop a first episode of mania can be identified during the prodromal phase. The proposed criteria need further evaluation in prospective clinical trials.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Journal of Affective Disorders | ||||
Publisher: | Elsevier Science BV | ||||
ISSN: | 0165-0327 | ||||
Official Date: | December 2010 | ||||
Dates: |
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Volume: | 127 | ||||
Number: | 1-3 | ||||
Page Range: | pp. 316-320 | ||||
DOI: | 10.1016/j.jad.2010.06.016 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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