The Library
The cerebral venous system and hypoxia
Tools
Wilson, Mark Howard and Imray, C. (Chris) (2015) The cerebral venous system and hypoxia. Journal of Applied Physiology . jap.00327.2015. doi:10.1152/japplphysiol.00327.2015 ISSN 8750-7587.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1152/japplphysiol.00327.2015
Abstract
Most hypobaric hypoxia studies have focused on oxygen delivery and therefore cerebral blood inflow. Few have studied venous outflow. However, the volume of blood entering and leaving the skull (approximately 700mls/min) is considerably greater than CSF production (0.35mls/min) or edema formation rates and slight imbalances of in- and out-flow have considerable effects on intracranial pressure (ICP). This dynamic phenomenon is not necessarily appreciated in the currently taught static "Monro-Kellie" doctrine which forms the basis of the "Tight-Fit" hypothesis thought to under lie high altitude headache, acute mountain sickness (AMS) and High Altitude Cerebral Edema (HACE). Investigating both sides of the cerebral circulation was an integral part of the 2007 Xtreme Everest Expedition. The results of the relevant studies performed as part of and subsequent to this expedition are reviewed here. The evidence from recent studies suggests a relative venous outflow insufficiency is an early step in the pathogenesis of high altitude headache. Translation of knowledge gained from high altitude studies is important. Many patients in a critical care environment develop hypoxemia akin to that of high altitude exposure. An inability to drain the hypoxemic induced increase in cerebral blood flow could be an underappreciated regulatory mechanism of intracranial pressure.
Item Type: | Journal Article | ||||||||
---|---|---|---|---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||||||
Journal or Publication Title: | Journal of Applied Physiology | ||||||||
Publisher: | American Physiological Society | ||||||||
ISSN: | 8750-7587 | ||||||||
Official Date: | 20 August 2015 | ||||||||
Dates: |
|
||||||||
Article Number: | jap.00327.2015 | ||||||||
DOI: | 10.1152/japplphysiol.00327.2015 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |