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Well-defined protein/peptide–polymer conjugates by aqueous Cu-LRP : synthesis and controlled self-assembly
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Zhang, Qiang, Li, Muxiu, Zhu, Chongyu, Nurumbetov, Gabit, Li, Zaidong, Wilson, Paul, Kempe, Kristian and Haddleton, David M. (2015) Well-defined protein/peptide–polymer conjugates by aqueous Cu-LRP : synthesis and controlled self-assembly. Journal of the American Chemical Society, 137 (29). pp. 9344-9353. doi:10.1021/jacs.5b04139 ISSN 0002-7863.
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Official URL: http://dx.doi.org/10.1021/jacs.5b04139
Abstract
The synthesis of well-defined protein/peptide–polymer conjugates with interesting self-assembly behavior via single electron transfer living radical polymerization in water is described. A range of protein/peptides with different physical and chemical properties have been modified to macroinitiators and optimized polymerization conditions ensure successful polymerization from soluble, insoluble, and dispersed protein/peptide molecules or protein aggregates. This powerful strategy tolerates a range of functional monomers and mediates efficient homo or block copolymerization to generate hydrophilic polymers with controlled molecular weight (MW) and narrow MW distribution. The polymerizations from bovine insulin macroinitiators follow surface-initiated “grafting from” polymerization mechanism and may involve a series of self-assembly and disassembly processes. Synthesized insulin-polymer conjugates form spheres in water, and the self-assembly behavior could be controlled via thermal control, carbohydrate–protein interaction, and protein denaturation.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||
Journal or Publication Title: | Journal of the American Chemical Society | ||||||
Publisher: | American Chemical Society | ||||||
ISSN: | 0002-7863 | ||||||
Official Date: | 7 July 2015 | ||||||
Dates: |
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Volume: | 137 | ||||||
Number: | 29 | ||||||
Page Range: | pp. 9344-9353 | ||||||
DOI: | 10.1021/jacs.5b04139 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access |
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