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Omega-3 fatty acid supplementation in adolescents with borderline personality disorder and ultra-high risk criteria for psychosis: a post hoc subgroup analysis of a double-blind, randomized controlled trial.
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Amminger, G. P., Chanen, Andrew M., Ohmann, S, Klier, Claudia M., Mossaheb, N., Bechdolf, Andreas, Nelson, B., Thompson, Andrew D., McGorry, Patrick D., Yung , A. R. and Schäfer, M. R. (2013) Omega-3 fatty acid supplementation in adolescents with borderline personality disorder and ultra-high risk criteria for psychosis: a post hoc subgroup analysis of a double-blind, randomized controlled trial. Canadian Journal of Psychiatry, 58 (7). pp. 402-408. ISSN 0706-7437.
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Official URL: http://publications.cpa-apc.org/media.php?mid=1542
Abstract
OBJECTIVE:
To investigate whether long-chain omega-3 (n-3) polyunsaturated fatty acids (PUFAs) improve functioning and psychiatric symptoms in young people with borderline personality disorder (BPD) who also meet ultra-high risk criteria for psychosis.
METHODS:
We conducted a post hoc subgroup analysis of a double-blind, randomized controlled trial. Fifteen adolescents with BPD (mean age 16.2 years, [SD 2.1]) were randomized to either 1.2 g/day n-3 PUFAs or placebo. The intervention period was 12 weeks. Study measures included the Positive and Negative Syndrome Scale, the Montgomery-Åsberg Depression Rating Scale, and the Global Assessment of Functioning. Side effects were documented with the Udvalg for Kliniske Undersøgelser. Fatty acids in erythrocytes were analyzed using capillary gas chromatography.
RESULTS:
At baseline, erythrocyte n-3 PUFA levels correlated positively with psychosocial functioning and negatively with psychopathology. By the end of the intervention, n-3 PUFAs significantly improved functioning and reduced psychiatric symptoms, compared with placebo. Side effects did not differ between the treatment groups.
CONCLUSIONS:
Long-chain n-3 PUFAs should be further explored as a viable treatment strategy with minimal associated risk in young people with BPD.
(CLINICAL TRIAL REGISTRATION NUMBER:NCT00396643).
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Canadian Journal of Psychiatry | ||||
Publisher: | Sage Publications, Inc. | ||||
ISSN: | 0706-7437 | ||||
Official Date: | July 2013 | ||||
Dates: |
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Volume: | 58 | ||||
Number: | 7 | ||||
Page Range: | pp. 402-408 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
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