The Library
The pneumonia virus of mice infection model for severe respiratory syncytial virus infection: identifying novel targets for therapeutic intervention
Tools
UNSPECIFIED (2005) The pneumonia virus of mice infection model for severe respiratory syncytial virus infection: identifying novel targets for therapeutic intervention. PHARMACOLOGY & THERAPEUTICS, 105 (1). pp. 1-6. doi:10.1016/j.pharmthera.2004.09.001
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1016/j.pharmthera.2004.09.001
Abstract
Pneumonia virus of mice (PVM) is the first infection model that replicates features of severe human respiratory syncytial virus (hRSV) disease in the mouse. The PVM model has highlighted the importance of inflammation to the pathogenesis of severe disease, demonstrating that the inflammatory response remains active and acute even when virus replication ceases in response to appropriate antiviral therapy. The fact that the inflammatory response continues and is not completely linked to ongoing virus replication indicates the need for concurrent anti-inflammatory or, ideally, specific immunomodulatory therapy. The chemokine macrophage inflammatory protein-1alpha (MIP-1alpha) and its receptor, CC chemokine receptor I (CCR1), have been identified as crucial to the inflammatory response to PVM and hRSV and thus as elements to exploit for potential immunomodulatory control. Biochemical blockade of MIP-1alpha signaling with the CCR1 antagonist met-RANTES prevents the inflammatory response to PVM and results in reduced morbidity and mortality when administered in conjunction with the antiviral agent ribavirin. Ongoing exploration into the biology of PVM infection will identify other pathways and targets to be exploited for immunomodulatory control of hRSV and related severe respiratory virus infections. (C) 2004 Elsevier Inc. All rights reserved.
Item Type: | Journal Item | ||||
---|---|---|---|---|---|
Subjects: | R Medicine > RS Pharmacy and materia medica | ||||
Journal or Publication Title: | PHARMACOLOGY & THERAPEUTICS | ||||
Publisher: | PERGAMON-ELSEVIER SCIENCE LTD | ||||
ISSN: | 0163-7258 | ||||
Official Date: | January 2005 | ||||
Dates: |
|
||||
Volume: | 105 | ||||
Number: | 1 | ||||
Number of Pages: | 6 | ||||
Page Range: | pp. 1-6 | ||||
DOI: | 10.1016/j.pharmthera.2004.09.001 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |