The Library
Brominated variant of the Lantibiotic NAI-107 with enhanced antibacterial potency
Tools
Cruz, João C. S., Iorio, Marianna, Monciardini, Paolo, Simone, Matteo, Brunati, Cristina, Gaspari, Eleonora, Maffioli, Sonia I., Wellington, E. M. H., Sosio, Margherita and Donadio, Stefano (2015) Brominated variant of the Lantibiotic NAI-107 with enhanced antibacterial potency. Journal of Natural Products, 78 (11). pp. 2642-2647. doi:10.1021/acs.jnatprod.5b00576 ISSN 0163-3864.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1021/acs.jnatprod.5b00576
Abstract
We identified an Actinoallomurus strain producing NAI-107, a chlorinated lantibiotic effective against multidrug-resistant Gram-positive pathogens and previously reported from the distantly related genus Microbispora. Inclusion of KBr in the production medium of either the Actinoallomurus or the Microbispora producer readily afforded brominated variants of NAI-107, which were designated as NAI-108. The other post-translational modifications naturally occurring in this lantibiotic family (i.e., hydroxylation of Pro-14 and C-terminal decarboxylation) were unaffected by the presence of a brominated tryptophan. In addition to being the first example of a bromine-containing lantibiotic, NAI-108 displayed a small but consistent improvement in antibacterial activity against all tested strains. The brominated lantibiotic maintained the same rapid bactericidal activity as NAI-107 but at reduced concentrations, consistent with its increased potency and with the role played by the hydrophobicity of the first lanthionine ring. NAI-108 thus represents an interesting addition to a promising family of potent and effective lantibiotics.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | Journal of Natural Products | ||||
Publisher: | ACS | ||||
ISSN: | 0163-3864 | ||||
Official Date: | 29 October 2015 | ||||
Dates: |
|
||||
Volume: | 78 | ||||
Number: | 11 | ||||
Page Range: | pp. 2642-2647 | ||||
DOI: | 10.1021/acs.jnatprod.5b00576 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |