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Phenotypic and genotypic characteristics of small colony variants and their role in chronic infection
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Maddocks, Sarah Elizabeth, Johns, Benjamin, Purdy, Kevin J. and Tucker, Nicholas (2015) Phenotypic and genotypic characteristics of small colony variants and their role in chronic infection. Microbiology Insights . pp. 15-23. doi:10.4137/MBI.S25800 ISSN 1178-6361.
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Official URL: http://dx.doi.org/10.4137/MBI.S25800
Abstract
Small colony variant (SCV) bacteria arise spontaneously within apparently homogeneous microbial populations, largely in response to environmental stresses, such as antimicrobial treatment. They display unique phenotypic characteristics conferred in part by heritable genetic changes. Characteristically slow growing, SCVs comprise a minor proportion of the population from which they arise but persist by virtue of their inherent resilience and host adaptability. Consequently, SCVs are problematic in chronic infection, where antimicrobial treatment is administered during the acute phase of infection but fails to eradicate SCVs, which remain within the host causing recurrent or chronic infection. This review discusses some of the phenotypic and genotypic changes that enable SCVs to successfully proliferate within the host environment as potential pathogens and strategies that could ameliorate the resolution of infection where SCVs are present.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QR Microbiology | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
Library of Congress Subject Headings (LCSH): | Phenotype, Microbiology, Biofilms, Bacteriology, Cell culture | ||||||||
Journal or Publication Title: | Microbiology Insights | ||||||||
Publisher: | Libertas Academica Ltd. | ||||||||
ISSN: | 1178-6361 | ||||||||
Official Date: | 22 September 2015 | ||||||||
Dates: |
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Page Range: | pp. 15-23 | ||||||||
DOI: | 10.4137/MBI.S25800 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 13 January 2016 | ||||||||
Date of first compliant Open Access: | 13 January 2016 |
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