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Tetraaza[14]macrocyclic transition metal complexes as DNA intercalators
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Mames, Iwona, Rodger, Alison and Kowalski, Jarosław (2015) Tetraaza[14]macrocyclic transition metal complexes as DNA intercalators. European Journal of Inorganic Chemistry, 2015 (4). pp. 630-639. doi:10.1002/ejic.201403042 ISSN 1434-1948.
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Official URL: http://dx.doi.org/10.1002/ejic.201403042
Abstract
Six tetraazamacrocyclic copper(II) and nickel(II) complexes have been synthesised and their interactions with double-stranded DNA (calf thymus DNA) have been studied using circular and linear dichroism, as well as other spectroscopic methods. The ability of these complexes to intercalate between DNA base pairs has been demonstrated qualitatively and confirmed by determining the stoichiometry and association constant values; these were found to range from 8.5 × 103 – 2.8 × 104 L mol–1. The nickel(II) complexes, being more electron-deficient, seem to have higher binding abilities than guests containing the copper ion. It has also been shown that not only CD, but also linear dichroism, can be a very useful tool for carrying out qualitative DNA interaction studies.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QD Chemistry | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
Library of Congress Subject Headings (LCSH): | Transition metal complexes, DNA-ligand interactions, Macrocyclic compounds | ||||||||
Journal or Publication Title: | European Journal of Inorganic Chemistry | ||||||||
Publisher: | Wiley-VCH Verlag GMBH | ||||||||
ISSN: | 1434-1948 | ||||||||
Official Date: | February 2015 | ||||||||
Dates: |
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Volume: | 2015 | ||||||||
Number: | 4 | ||||||||
Page Range: | pp. 630-639 | ||||||||
DOI: | 10.1002/ejic.201403042 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 13 January 2016 | ||||||||
Date of first compliant Open Access: | 13 January 2016 | ||||||||
Funder: | Foundation For Polish Science (Fundacja na rzecz Nauki Polskiej, FNP) | ||||||||
Grant number: | HOMING PLUS/2011-3/6 |
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