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Speciation of precious metal anti-cancer complexes by NMR spectroscopy
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Zou, Taotao and Sadler, P. J. (2015) Speciation of precious metal anti-cancer complexes by NMR spectroscopy. Drug Discovery Today : Technologies, 16 . pp. 7-15. doi:10.1016/j.ddtec.2015.08.002 ISSN 1740-6749.
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Official URL: http://dx.doi.org/10.1016/j.ddtec.2015.08.002
Abstract
Understanding the mechanism of action of anti-cancer agents is of paramount importance for drug development. NMR spectroscopy can provide insights into the kinetics and thermodynamics of the binding of metallodrugs to biomolecules. NMR is most sensitive for highly abundant I = 1/2 nuclei with large magnetic moments. Polarization transfer can enhance NMR signals of insensitive nuclei at physiologically-relevant concentrations. This paper reviews NMR methods for speciation of precious metal anti-cancer complexes, including platinum-group and gold-based anti-cancer agents. Examples of NMR studies involving interactions with DNA and proteins in particular are highlighted.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QD Chemistry R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Nuclear magnetic resonance spectroscopy, Antineoplastic agents, Cisplatin, Oxaliplatin, Precious metals | ||||
Journal or Publication Title: | Drug Discovery Today : Technologies | ||||
Publisher: | Elsevier | ||||
ISSN: | 1740-6749 | ||||
Official Date: | 11 September 2015 | ||||
Dates: |
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Volume: | 16 | ||||
Page Range: | pp. 7-15 | ||||
DOI: | 10.1016/j.ddtec.2015.08.002 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Date of first compliant deposit: | 13 January 2016 | ||||
Date of first compliant Open Access: | 19 February 2016 | ||||
Funder: | European Research Council (ERC), Engineering and Physical Sciences Research Council (EPSRC) | ||||
Grant number: | 247450 ERC, EP/F034210/1 EPSRC |
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