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Chemical chain termination resolves the timing of ketoreduction in a partially reducing iterative type I polyketide synthase
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Kage, Hirokazu, Riva, Elena, Parascandolo, James S., Kreutzer, Martin F., Tosin, Manuela and Nett, Markus (2015) Chemical chain termination resolves the timing of ketoreduction in a partially reducing iterative type I polyketide synthase. Organic & Biomolecular Chemistry, 13 (47). pp. 11414-11417. doi:10.1039/c5ob02009c ISSN 1477-0520.
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Official URL: http://dx.doi.org/10.1039/C5OB02009C
Abstract
Synthetic chain terminators were used to capture the biosynthetic intermediates from a partially reducing iterative type I polyketide synthase, which is integrated into a multimodular biosynthesis enzyme. The off-loaded metabolites clarified the timing of ketoreduction and aromatization in the assembly of the antibiotic micacocidin.
Item Type: | Journal Article | ||||||||||
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Subjects: | Q Science > QD Chemistry | ||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||
Library of Congress Subject Headings (LCSH): | Polyketides -- Synthesis, Natural products -- Metabolism | ||||||||||
Journal or Publication Title: | Organic & Biomolecular Chemistry | ||||||||||
Publisher: | Royal Society of Chemistry | ||||||||||
ISSN: | 1477-0520 | ||||||||||
Official Date: | 21 December 2015 | ||||||||||
Dates: |
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Volume: | 13 | ||||||||||
Number: | 47 | ||||||||||
Page Range: | pp. 11414-11417 | ||||||||||
DOI: | 10.1039/c5ob02009c | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
Date of first compliant deposit: | 28 January 2016 | ||||||||||
Date of first compliant Open Access: | 1 February 2016 | ||||||||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), Leibniz-Gemeinschaft | ||||||||||
Grant number: | BB/J007250/1 |
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