Gay, N. J., Vyse, A. J., Enquselassie, F., Nigatu, Wondatir and Nokes, D. James (2003) Improving sensitivity of oral fluid testing in IgG prevalence studies: application of mixture models to a rubella antibody survey. Epidemiology and Infection, Vol.13 (No.2). pp. 285-291. doi:10.1017/S0950268802008051 ISSN 0950-2688.

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Abstract

A method for the analysis of age-stratified antibody prevalence surveys is applied to a previously reported survey of antibody to rubella virus using oral fluid samples in which the sensitivity of the assay used was shown to be compromised. The age-specific distribution of the quantitative results of antibody tests using oral fluids is modelled as a mixture of strong positive, weak positive and negative components. This yields maximum likelihood estimates of the prevalence at each age and demonstrates that, when used in conjunction with mixture modelling techniques, the results of antibody prevalence studies using oral fluids accurately reflect those obtained using sera.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology > QR355 Virology
Divisions:	Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Library of Congress Subject Headings (LCSH):	Rubella virus, Viruses -- Identification, Viruses -- Isolation, Viral antibodies, Viruses -- Research
Journal or Publication Title:	Epidemiology and Infection
Publisher:	Cambridge University Press
ISSN:	0950-2688
Official Date:	April 2003
Dates:	Date Event April 2003 Published
Volume:	Vol.13
Number:	No.2
Page Range:	pp. 285-291
DOI:	10.1017/S0950268802008051
Status:	Peer Reviewed
Access rights to Published version:	Restricted or Subscription Access
Funder:	Wellcome Trust (London, England)
Grant number:	047413 (Wellcome)

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