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Type I error control in biomarker-stratified clinical trials
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Parashar, D., Bowden, Jack, Starr, Colin, Wernisch, Lorenz and Mander, Adrian (2015) Type I error control in biomarker-stratified clinical trials. In: 3rd International Clinical Trials Methodology Conference, Glasgow SECC, UK, 16-17 Nov 2015. Published in: Trials, 16 (Suppl 2). O84. doi:10.1186/1745-6215-16-S2-O84 ISSN 1745-6215.
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Official URL: http://dx.doi.org/10.1186/1745-6215-16-S2-O84
Abstract
Biomarker-stratified clinical trials assess the biomarker signature of subjects and split them into subgroups so that treatment is of benefit to those who are likely to respond. Since multiple hypotheses are tested, it becomes important to control the type I error. Current methods control the false positive rate where one rejects the null hypothesis while in reality that was true. For two subgroups, the false positive rate is controlled across the two hypotheses as a Family Wise Error Rate (FWER) to an overall predetermined significance level.
Item Type: | Conference Item (Speech) | ||||
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Subjects: | Q Science > QH Natural history | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Cancer Research Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Biochemical markers | ||||
Journal or Publication Title: | Trials | ||||
Publisher: | Biomed Central | ||||
ISSN: | 1745-6215 | ||||
Official Date: | 2015 | ||||
Dates: |
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Volume: | 16 | ||||
Number: | Suppl 2 | ||||
Page Range: | O84 | ||||
DOI: | 10.1186/1745-6215-16-S2-O84 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Open Access (Creative Commons) | ||||
Conference Paper Type: | Speech | ||||
Title of Event: | 3rd International Clinical Trials Methodology Conference | ||||
Type of Event: | Conference | ||||
Location of Event: | Glasgow SECC, UK | ||||
Date(s) of Event: | 16-17 Nov 2015 |
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