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Heparin-stabilised iron oxide for MR applications : a relaxometric study
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Ternent, Lucy, Mayoh, Daniel, Lees, Martin R. and Davies, Gemma L. (2016) Heparin-stabilised iron oxide for MR applications : a relaxometric study. Journal of Materials Chemistry B, 4 . pp. 3065-3074. doi:10.1039/c6tb00832a ISSN 2050-750X.
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WRAP_GLDavies_HeparinFe3O4_JMCB_revised manuscript.pdf - Accepted Version - Requires a PDF viewer. Download (1061Kb) | Preview |
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WRAP_ESI_GLDavies_HeparinFe3O4_JMCB_revised.pdf - Accepted Version - Requires a PDF viewer. Download (212Kb) | Preview |
Official URL: http://dx.doi.org/10.1039/C6TB00832A
Abstract
Superparamagnetic nanoparticles have strong potential in biomedicine and have seen application as clinical magnetic resonance imaging (MRI) contrast agents, though their popularity has plummeted in recent years, due to low efficacy and safety concerns, including haemagglutination. Using an in situ procedure, we have prepared colloids of magnetite nanoparticles, exploiting the clinically approved anti-coagulant, heparin, as a templating stabiliser. These colloids, stable over several days, produce exceptionally strong MRI contrast capabilities particularly at low fields, as demonstrated by relaxometric investigations using nuclear magnetic resonance dispersion (NMRD) techniques and single field r1 and r2 relaxation measurements. This behaviour is due to interparticle interactions, enhanced by the templating effect of heparin, resulting in strong magnetic anisotropic behaviour which closely maps particle size. The nanocomposites have also reliably prevented protein-adsorption triggered thrombosis typical of non-stabilised nanoparticles, showing great potential for in vivo MRI diagnostics.
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | Q Science > QR Microbiology | |||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Research Centres > Molecular Organisation and Assembly in Cells (MOAC) Faculty of Science, Engineering and Medicine > Science > Physics |
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| Library of Congress Subject Headings (LCSH): | Heparin, Paramagnetism | |||||||||||||||
| Journal or Publication Title: | Journal of Materials Chemistry B | |||||||||||||||
| Publisher: | R S C Publications | |||||||||||||||
| ISSN: | 2050-750X | |||||||||||||||
| Official Date: | 15 April 2016 | |||||||||||||||
| Dates: |
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| Volume: | 4 | |||||||||||||||
| Number of Pages: | 10 | |||||||||||||||
| Page Range: | pp. 3065-3074 | |||||||||||||||
| DOI: | 10.1039/c6tb00832a | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||
| Date of first compliant deposit: | 3 May 2016 | |||||||||||||||
| Date of first compliant Open Access: | 15 April 2017 | |||||||||||||||
| RIOXX Funder/Project Grant: |
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