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Overproduction and identification of butyrolactones SCB1-8 in the antibiotic production superhost Streptomyces M1152
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Sidda, John D., Poon, Vincent, Song, Lijiang, Wang, Weishan, Yang, Keqian and Corre, Christophe (2016) Overproduction and identification of butyrolactones SCB1-8 in the antibiotic production superhost Streptomyces M1152. Organic and Biomolecular Chemistry, 14 . pp. 6390-6393. doi:10.1039/c6ob00840b ISSN 1477-0520.
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Official URL: http://dx.doi.org/10.1039/C6OB00840B
Abstract
Gamma-butyrolactones (GBLs) are signalling molecules that control antibiotic production in Streptomyces bacteria. The genetically engineered strain S. coelicolor M1152 was found to overproduce GBLs SCB1-3 as well as five novel GBLs named SCB4-8. Incorporation experiments using isotopically-labelled precursors confirmed the chemical structures of SCB1-3 and established those of SCB4-8.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QD Chemistry R Medicine > R Medicine (General) |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
Library of Congress Subject Headings (LCSH): | Streptomyces, Antibiotics, Metabolites | ||||||||
Journal or Publication Title: | Organic and Biomolecular Chemistry | ||||||||
Publisher: | RSC | ||||||||
ISSN: | 1477-0520 | ||||||||
Official Date: | 10 May 2016 | ||||||||
Dates: |
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Volume: | 14 | ||||||||
Page Range: | pp. 6390-6393 | ||||||||
DOI: | 10.1039/c6ob00840b | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 11 May 2016 | ||||||||
Date of first compliant Open Access: | 10 May 2017 | ||||||||
Funder: | Royal Society (Great Britain), Engineering and Physical Sciences Research Council (EPSRC), Guo jia zi ran ke xue ji jin wei yuan hui (China) [National Natural Science Foundation of China] (NSFC) | ||||||||
Grant number: | (UF090255) (Royal Society), 31570031 (China) | ||||||||
Is Part Of: | Funder: EPSRC DTA, Royal Society University Research Fellowship (UF090255), National Natural Science Foundation of China 31570031 | ||||||||
Open Access Version: |
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