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Association between stressful life events and psychotic experiences in adolescence : evidence for gene-environment correlations
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Shakoor, Sania, Zavos, Helena M. S., Haworth, Claire M. A., McGuire, Philip, Cardno, Alastair G., Freeman, Daniel and Ronald, Angelica (2016) Association between stressful life events and psychotic experiences in adolescence : evidence for gene-environment correlations. The British Journal of Psychiatry, 208 (6). pp. 532-538. doi:10.1192/bjp.bp.114.159079 ISSN 0007-1250.
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Official URL: http://dx.doi.org/10.1192/bjp.bp.114.159079
Abstract
Background:
Stressful life events (SLEs) are associated with psychotic experiences. SLEs might act as an environmental risk factor, but may also share a genetic propensity with psychotic experiences.
Aims:
To estimate the extent to which genetic and environmental factors influence the relationship between SLEs and psychotic experiences.
Method:
Self- and parent reports from a community-based twin sample (4830 16-year-old pairs) were analysed using structural equation model fitting.
Results
SLEs correlated with positive psychotic experiences (r = 0.12–0.14, all P50.001). Modest heritability was shown for psychotic experiences (25–57%) and dependent SLEs (32%). Genetic influences explained the majority of the modest covariation between dependent SLEs and paranoia and cognitive disorganisation (bivariate heritabilities 74–86%). The relationship between SLEs and hallucinations and grandiosity was explained by both genetic and common environmental effects.
Conclusions:
Further to dependent SLEs being an environmental risk factor, individuals may have an underlying genetic propensity increasing their risk of dependent SLEs and positive psychotic experiences.
Item Type: | Journal Article | ||||||
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Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||
Library of Congress Subject Headings (LCSH): | Stress (Psychology), Psychoses | ||||||
Journal or Publication Title: | The British Journal of Psychiatry | ||||||
Publisher: | Royal College of Psychiatrists | ||||||
ISSN: | 0007-1250 | ||||||
Official Date: | June 2016 | ||||||
Dates: |
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Volume: | 208 | ||||||
Number: | 6 | ||||||
Number of Pages: | 7 | ||||||
Page Range: | pp. 532-538 | ||||||
DOI: | 10.1192/bjp.bp.114.159079 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Description: | Data to supplement paper available at the end of the document. |
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Date of first compliant deposit: | 18 May 2016 | ||||||
Date of first compliant Open Access: | 26 May 2016 | ||||||
Funder: | Medical Research Council (Great Britain) (MRC), British Academy (BA) | ||||||
Grant number: | G11005599(MRC), G0901245 (MRC), G0500079 (MRC), G0902308 (MRC) |
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