Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Dicarbonyl stress in clinical obesity

Tools
- Tools
+ Tools

Masania, Jinit , Malczewska-Malec, Malgorzata, Razny, Urszula, Goralska, Joanna, Zdzienicka, Anna, Kiec-Wilk, Beata, Gruca, Anna, Stancel-Mozwillo, Julita, Dembinska-Kiec, Aldona, Rabbani, Naila and Thornalley, Paul J. (2016) Dicarbonyl stress in clinical obesity. Glycoconjugates Journal, 33 (4). pp. 581-589. doi:10.1007/s10719-016-9692-0 ISSN 0282-0080.

[img] PDF
WRAP_3A10.1007%2Fs10719-016-9692-0.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution 4.0.

Download (1011Kb)
[img] PDF
WRAP_0670584-mv-290516-glyc-d-16-00035.pdf - Accepted Version
Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer.

Download (1370Kb)
Official URL: http://dx.doi.org/10.1007/s10719-016-9692-0

Request Changes to record.

Abstract

The glyoxalase system in the cytoplasm of cells provides the primary defence against glycation by methylglyoxal catalysing its metabolism to D-lactate. Methylglyoxal is the precursor of the major quantitative advanced glycation endproducts in physiological systems - arginine-derived hydroimidazolones and deoxyguanosine-derived imidazopurinones. Glyoxalase 1 of the glyoxalase system was linked to anthropometric measurements of obesity in human subjects and to body weight in strains of mice. Recent conference reports described increased weight gain on high fat diet-fed mouse with lifelong deficiency of glyoxalase 1 deficiency, compared to wild-type controls, and decreased weight gain in glyoxalase 1- overexpressing transgenic mice, suggesting a functional role of glyoxalase 1 and dicarbonyl stress in obesity. Increased methylglyoxal, dicarbonyl stress, in white adipose tissue and liver may be a mediator of obesity and insulin resistance and thereby a risk factor for development of type 2 diabetes and non-alcoholic fatty liver disease. Increased methylglyoxal formation from glyceroneogenesis on adipose tissue and liver and decreased glyoxalase 1 activity in obesity likely drives dicarbonyl stress in white adipose tissue increasing the dicarbonyl proteome and related dysfunction. The clinical significance will likely emerge from on-going clinical evaluation of inducers of glyoxalase 1 expression in overweight and obese subjects. Increased transcapillary escape rate of albumin and increased total body interstitial fluid volume in obesity likely makes levels of glycation of plasma protein unreliable indicators of glycation status in obesity as there is a shift of albumin dwell time from plasma to interstitial fluid which decreases overall glycation for a given glycemic exposure.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016)
Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Glycosylation , Glyoxalase, Obesity, Insulin resistance , Inflammation , Non-insulin-dependent diabetes, Cardiovascular system -- Diseases
Journal or Publication Title: Glycoconjugates Journal
Publisher: Springer New York LLC
ISSN: 0282-0080
Official Date: August 2016
Dates:
DateEvent
August 2016Published
24 June 2016Available
27 May 2016Accepted
2 March 2016Submitted
Volume: 33
Number: 4
Page Range: pp. 581-589
DOI: 10.1007/s10719-016-9692-0
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 31 May 2016
Date of first compliant Open Access: 22 August 2016
Funder: Seventh Framework Programme (European Commission) (FP7)
Grant number: 244995 (BIOCLAIMS Project)
Related URLs:
  • Publisher

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us