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Implementing nonlinear feedback controllers using DNA strand displacement reactions
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Sawlekar, Rucha, Montefusco, Francesco, Kulkarni, Vishwesh V. and Bates, Declan (2016) Implementing nonlinear feedback controllers using DNA strand displacement reactions. IEEE Transactions on NanoBioscience, 15 (5). 443 -454. doi:10.1109/TNB.2016.2560764 ISSN 1536-1241.
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Official URL: http://dx.doi.org/10.1109/TNB.2016.2560764
Abstract
We show how an important class of nonlinear feedback controllers can be designed using idealized abstract chemical reactions and implemented via DNA strand displacement (DSD) reactions. Exploiting chemical reaction networks (CRNs) as a programming language for the design of complex circuits and networks, we show how a set of unimolecular and bimolecular reactions can be used to realize input-output dynamics that produce a nonlinear quasi sliding mode (QSM) feedback controller. The kinetics of the required chemical reactions can then be implemented as enzyme-free, enthalpy/entropy driven DNA reactions using a toehold mediated strand displacement mechanism via Watson-Crick base pairing and branch migration. We demonstrate that the closed loop response of the nonlinear QSM controller outperforms a traditional linear controller by facilitating much faster tracking response dynamics without introducing overshoots in the transient response. The resulting controller is highly modular and is less affected by retroactivity effects than standard linear designs.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QH Natural history > QH426 Genetics T Technology > TJ Mechanical engineering and machinery |
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||||
Library of Congress Subject Headings (LCSH): | Feedback control systems, Sliding mode control , Chemical reactions, Unimolecular reactions | ||||||||
Journal or Publication Title: | IEEE Transactions on NanoBioscience | ||||||||
Publisher: | IEEE | ||||||||
ISSN: | 1536-1241 | ||||||||
Official Date: | July 2016 | ||||||||
Dates: |
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Volume: | 15 | ||||||||
Number: | 5 | ||||||||
Page Range: | 443 -454 | ||||||||
DOI: | 10.1109/TNB.2016.2560764 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 31 August 2016 | ||||||||
Date of first compliant Open Access: | 31 August 2016 | ||||||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), University of Warwick. Department of Engineering | ||||||||
Grant number: | BB/M017982/1 (BBSRC) |
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