Nev, Olga and Berg, Hugo van den (2017) Variable-Internal-Stores models of microbial growth and metabolism with dynamic allocation of cellular resources. Journal of Mathematical Biology, 74 (1-2). pp. 409-445. doi:10.1007/s00285-016-1030-4 ISSN 0303-6812.

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Abstract

Variable-Internal-Stores models of microbial metabolism and growth have proven to be invaluable in accounting for changes in cellular composition as microbial cells adapt to varying conditions of nutrient availability. Here, such a model is extended with explicit allocation of molecular building blocks among various types of catalytic machinery. Such an extension allows a reconstruction of the regulatory rules employed by the cell as it adapts its physiology to changing environmental conditions. Moreover, the extension proposed here creates a link between classic models of microbial growth and analyses based on detailed transcriptomics and proteomics data sets. We ascertain the compatibility between the extended Variable-Internal-Stores model and the classic models, demonstrate its behaviour by means of simulations, and provide a detailed treatment of the uniqueness and the stability of its equilibrium point as a function of the availabilities of the various nutrients

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology
Divisions:	Faculty of Science, Engineering and Medicine > Science > Mathematics
Library of Congress Subject Headings (LCSH):	Microbial growth, Microbial metabolism, Cell physiology, Proteomics
Journal or Publication Title:	Journal of Mathematical Biology
Publisher:	Springer
ISSN:	0303-6812
Official Date:	January 2017
Dates:	Date Event January 2017 Published 6 June 2016 Available 16 May 2016 Accepted
Volume:	74
Number:	1-2
Number of Pages:	37
Page Range:	pp. 409-445
DOI:	10.1007/s00285-016-1030-4
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access (Creative Commons)
Date of first compliant deposit:	2 June 2016
Date of first compliant Open Access:	3 August 2016
Funder:	Seventh Framework Programme (European Commission) (FP7), Marie Skłodowska-Curie actions

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