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Collagen matrix stiffness influencing on fibroblast contraction force
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Jin, Tianrong, Li, Li, Siow, R. C. M. and Liu, Kuo-Kang (2016) Collagen matrix stiffness influencing on fibroblast contraction force. In: 10th World Biomaterials Congress, Montréal, Canada, 17-22 May 2016. Published in: Frontiers in Bioengineering and Biotechnology , 4 doi:10.3389/conf.FBIOE.2016.01.01917 ISSN 2296-4185.
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Official URL: http://dx.doi.org/10.3389/conf.FBIOE.2016.01.01917
Abstract
Fibroblast-seeded collagen gel which constructs a 3D bio-artificial extracellular matrix (ECM) has been widely used in wound healing, tissue engineering and regenerative medicine. Previous studies using fibroblast-populated collagen based assay to measure cell contractility were limited to examine the radius changes of gel and hence accurate determination of cell contraction force was difficult to achieve[1],[2]. Up to now, little has been known about how the stiffness of collagen matrix influences on cell contraction force. We have recently developed a novel nano-indentation device to measure the gel elasticity and in combination with a mathematical model, the cell contraction force can be determined accurately based on the measured gel thickness and area[3]. In this study, we apply the new technique to investigate the effect of gel stiffness on cell contraction force in a quantitative manner.
Item Type: | Conference Item (Paper) | ||||||
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Subjects: | R Medicine > R Medicine (General) | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||
Library of Congress Subject Headings (LCSH): | Tissue engineering, Collagen | ||||||
Journal or Publication Title: | Frontiers in Bioengineering and Biotechnology | ||||||
Publisher: | Frontiers Research Foundation | ||||||
ISSN: | 2296-4185 | ||||||
Official Date: | 30 March 2016 | ||||||
Dates: |
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Volume: | 4 | ||||||
Article Number: | 01917 | ||||||
DOI: | 10.3389/conf.FBIOE.2016.01.01917 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 8 June 2016 | ||||||
Date of first compliant Open Access: | 8 June 2016 | ||||||
Conference Paper Type: | Paper | ||||||
Title of Event: | 10th World Biomaterials Congress | ||||||
Type of Event: | Conference | ||||||
Location of Event: | Montréal, Canada | ||||||
Date(s) of Event: | 17-22 May 2016 | ||||||
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