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Allocyclinones, hyperchlorinated angucyclinones from Actinoallomurus
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Cruz, João C. S., Maffioli, Sonia I., Bernasconi, Alice, Brunati, Cristina, Gaspari, Eleonora, Sosio, Margherita, Wellington, E. M. H. and Donadio, Stefano (2016) Allocyclinones, hyperchlorinated angucyclinones from Actinoallomurus. The Journal of Antibiotics . doi:10.1038/ja.2016.62 ISSN 0021-8820.
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Official URL: http://dx.doi.org/10.1038/ja.2016.62
Abstract
A screening program on a limited number of strains belonging to the Actinoallomurus genus yielded a series of new angucyclinones. NMR and MS analyses established that these compounds are characterized by an unusual lactone ring and present up to four halogens per molecule, with one congener representing the first natural product containing a trichloromethyl substitution on an aromatic system. Remarkably, this family of metabolites seems to be produced by phylogenetically distinct Actinoallomurus isolates. Because of the unique structural features and wide distribution among Actinoallomurus, we have designated these angucyclinones as allocyclinones. Allocyclinones possess interesting activity against different Gram-positive bacteria, including antibiotic-resistant strains, with antibacterial potency increasing with the number of chlorine substituents. The tetrachlorinated compound is the most abundant congener in the allocyclinone complex.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
Journal or Publication Title: | The Journal of Antibiotics | ||||||
Publisher: | Nature Publishing Group | ||||||
ISSN: | 0021-8820 | ||||||
Official Date: | 25 May 2016 | ||||||
Dates: |
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DOI: | 10.1038/ja.2016.62 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||
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