Jin, Tianrong, Li, Li, Siow, Richard C. M. and Liu, Kuo-Kang (2016) Collagen matrix stiffness influences on fibroblast contraction force. Biomedical Physics & Engineering Express, 2 . 047002. doi:10.1088/2057-1976/2/4/047002 ISSN 2057-1976.

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Abstract

Cell-embedded hydrogel has been widely used as engineered tissue equivalents in biomedical applications. In this study, contraction force in human aortic adventitial fibroblasts seeded within a 3D collagen matrix was quantified by a novel force sensing technique. We demonstrate that contraction forces in cells treated with histamine are regulated by the gel stiffness in a linear manner. These findings provide novel insights for the design of collagen-based biomaterials for tissue engineering and clinical applications.

Item Type:	Journal Article
Subjects:	Q Science > QP Physiology R Medicine > R Medicine (General)
Divisions:	Faculty of Science, Engineering and Medicine > Engineering > Engineering
Library of Congress Subject Headings (LCSH):	Collagen, Colloids, Biomedical materials
Journal or Publication Title:	Biomedical Physics & Engineering Express
Publisher:	IOP Publishing
ISSN:	2057-1976
Official Date:	27 July 2016
Dates:	Date Event 27 July 2016 Published 7 June 2016 Accepted
Volume:	2
Article Number:	047002
DOI:	10.1088/2057-1976/2/4/047002
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Date of first compliant deposit:	14 June 2016
Date of first compliant Open Access:	27 July 2017
Funder:	Leverhulme Trust (LT), British Heart Foundation
Grant number:	PRG-2012-738 (LT), FS/09/037/27827 (BHF)

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