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Excited-state dynamics of a two-photon-activatable ruthenium prodrug
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Greenough, Simon E., Horbury, Michael D., Smith, Nichola A., Sadler, P. J., Paterson, Martin J. and Stavros, Vasilios G. (2016) Excited-state dynamics of a two-photon-activatable ruthenium prodrug. ChemPhysChem, 17 (2). pp. 221-224. doi:10.1002/cphc.201501075 ISSN 1439-4235.
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Official URL: http://dx.doi.org/10.1002/cphc.201501075
Abstract
We present a new approach to investigate how the photodynamics of an octahedral ruthenium(II) complex activated through two-photon absorption (TPA) differ from the equivalent complex activated through one-photon absorption (OPA). We photoactivated a RuII polypyridyl complex containing bioactive monodentate ligands in the photodynamic therapy window (620–1000 nm) by using TPA and used transient UV/Vis absorption spectroscopy to elucidate its reaction pathways. Density functional calculations allowed us to identify the nature of the initially populated states and kinetic analysis recovers a photoactivation lifetime of approximately 100 ps. The dynamics displayed following TPA or OPA are identical, showing that TPA prodrug design may use knowledge gathered from the more numerous and easily conducted OPA studies.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QD Chemistry | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
Library of Congress Subject Headings (LCSH): | Ruthenium, Excited state chemistry | ||||||||
Journal or Publication Title: | ChemPhysChem | ||||||||
Publisher: | Wiley | ||||||||
ISSN: | 1439-4235 | ||||||||
Official Date: | 6 January 2016 | ||||||||
Dates: |
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Volume: | 17 | ||||||||
Number: | 2 | ||||||||
Number of Pages: | 4 | ||||||||
Page Range: | pp. 221-224 | ||||||||
DOI: | 10.1002/cphc.201501075 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 23 June 2016 | ||||||||
Date of first compliant Open Access: | 23 June 2016 | ||||||||
Funder: | University of Warwick. Institute of Advanced Study (IAS), Engineering and Physical Sciences Research Council (EPSRC), European Research Council (ERC), Seventh Framework Programme (European Commission) (FP7), Royal Society (Great Britain) | ||||||||
Grant number: | EP/G006792/1 (EPSC), 247450 (ERC), 258990 (ERC), EP/H003401 (EPSRC) |
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