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The promising role of dynamic 18F-NaF PET-CT in diagnosing symptomatic joint prosthesis
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Adesanya, Oludolapo, Foguet, Pedro and Hutchinson, Charles E. (2015) The promising role of dynamic 18F-NaF PET-CT in diagnosing symptomatic joint prosthesis. Integrative Biomedical Sciences, 1 (2). pp. 64-69. ISSN 2469-4096.
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Official URL: http://www.gratisoa.org/journals/index.php/GJBS/ar...
Abstract
Our purpose was to establish proof of principle case study for the use of dynamic 18F-NaF PET-CT in the assessment of knee and hip prostheses. Approval was granted by the research ethics committee and informed consent was obtained. This is a case study investigating the role of dynamic 18F NaF PET-CT in a patient with bilateral knee prostheses (1 symptomatic/painful and 1 asymptomatic). Both knees were studied with dynamic 18F-NaF PET-CT technique to demonstrate the different pattern of uptake in normal/asymptomatic joint as well as painful joints with aseptic loosening. In addition, a knee aspirate was obtained from the symptomatic knee and serum C-reactive protein and erythrocyte sediment rate levels as well as a peripheral white cell count were obtained in addition to 12 month clinical follow up. Images were obtained with multi-sequential dynamic image acquisition in list mode using GE Healthcare® volume imaging protocol (ViP) after an intravenous injection of 250 MBq 18F-NaF. The images were interpreted as normal, loosening or septic loosening based on the graphical pattern of tracer uptake produced at the bone-prosthesis interface. A final diagnosis was made by a combination of joint aspiration microbiology and clinical follow-up for 1 year; in addition to C-reactive protein and erythrocyte sediment rate levels as well as peripheral white cell count. NaF PET results were compared with 3-phase dynamic bone scan results and plain radiographs. The degree of uptake in the symptomatic joint exceeded background levels and also levels of uptake in the asymptomatic knee. The pattern of uptake and curve slope in both the asymptomatic and symptomatic joints matched the pattern of uptake in our hypothesis. Dynamic 18F-NaF PET-CT is a useful imaging modality for assessing painful joint prosthesis. It can differentiate between asymptomatic joints and aseptic loosening. However, more work is required for the detection of septic loosening.
| Item Type: | Journal Article | |||||||||
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| Subjects: | R Medicine > RD Surgery | |||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Artificial knee, Artificial hip joints, C-reactive protein, Blood -- Sedimentation, Injections, Intravenous | |||||||||
| Journal or Publication Title: | Integrative Biomedical Sciences | |||||||||
| Publisher: | Gratis | |||||||||
| ISSN: | 2469-4096 | |||||||||
| Official Date: | 15 June 2015 | |||||||||
| Dates: |
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| Volume: | 1 | |||||||||
| Number: | 2 | |||||||||
| Page Range: | pp. 64-69 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||
| Copyright Holders: | Gratis | |||||||||
| Date of first compliant deposit: | 10 April 2018 | |||||||||
| Date of first compliant Open Access: | 10 April 2018 | |||||||||
| RIOXX Funder/Project Grant: |
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