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Regulation of the expression and activity of Unr in mammalian cells
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Anderson, Emma C. and Ó Catnaigh, Pól (2015) Regulation of the expression and activity of Unr in mammalian cells. Biochemical Society Transactions, 43 (6). pp. 1241-1246. doi:10.1042/BST20150165 ISSN 0300-5127.
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Official URL: http://dx.doi.org/10.1042/BST20150165
Abstract
Unr (upstream of N-ras) is a post-transcriptional regulator of gene expression, essential for mammalian development and mutated in many human cancers. The expression of unr is itself regulated at many levels; transcription of unr, which also affects expression of the downstream N-ras gene, is tissue and developmental stage-dependent and is repressed by c-Myc and Max (Myc associated factor X). Alternative splicing gives rise to six transcript variants, which include three different 5'-UTRs. The transcripts are further diversified by the use of three alternative polyadenylation signals, which governs whether AU-rich instability elements are present in the 3'-UTR or not. Translation of at least some unr transcripts can occur by internal initiation and is regulated in a cell-cycle-dependent manner; binding of PTB (polypyrimidine tract-binding protein) and Unr to the 5'-UTR inhibits translation, but these are displaced by heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNPC1/C2) during mitosis to stimulate translation. Finally, Unr is post-translationally modified by phosphorylation and lysine acetylation, although it is not yet known how these modifications affect Unr activity.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
| Journal or Publication Title: | Biochemical Society Transactions | ||||||
| Publisher: | Portland Press Ltd | ||||||
| ISSN: | 0300-5127 | ||||||
| Official Date: | 27 November 2015 | ||||||
| Dates: |
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| Volume: | 43 | ||||||
| Number: | 6 | ||||||
| Page Range: | pp. 1241-1246 | ||||||
| DOI: | 10.1042/BST20150165 | ||||||
| Status: | Not Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) | ||||||
| Grant number: | BB/J001791/1 |
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