The Library
Wider access to genotypic space facilitates loss of cooperation in a bacterial mutator
Tools
Harrison, Freya and Buckling, Angus (2011) Wider access to genotypic space facilitates loss of cooperation in a bacterial mutator. PLoS One, 6 (2). e17254. doi:10.1371/journal.pone.0017254 ISSN 1932-6203.
PDF
WRAP_journal.pone.0017254__.PDF - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution. Download (412Kb) |
Official URL: http://dx.doi.org/10.1371/journal.pone.0017254
Abstract
Understanding the ecological, evolutionary and genetic factors that affect the expression of cooperative behaviours is a topic of wide biological significance. On a practical level, this field of research is useful because many pathogenic microbes rely on the cooperative production of public goods (such as nutrient scavenging molecules, toxins and biofilm matrix components) in order to exploit their hosts. Understanding the evolutionary dynamics of cooperation is particularly relevant when considering long-term, chronic infections where there is significant potential for intra-host evolution. The impact of responses to non-social selection pressures on social evolution is arguably an under-examined area. In this paper, we consider how the evolution of a non-social trait – hypermutability – affects the cooperative production of iron-scavenging siderophores by the opportunistic human pathogen Pseudomonas aeruginosa. We confirm an earlier prediction that hypermutability accelerates the breakdown of cooperation due to increased sampling of genotypic space, allowing mutator lineages to generate non-cooperative genotypes with the ability to persist at high frequency and dominate populations. This may represent a novel cost of hypermutability.
Item Type: | Journal Article | ||||||
---|---|---|---|---|---|---|---|
Subjects: | Q Science > QR Microbiology | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
Library of Congress Subject Headings (LCSH): | Pseudomonas aeruginosa, Siderophores, Pathogenic microorganisms, Nosocomial infections | ||||||
Journal or Publication Title: | PLoS One | ||||||
Publisher: | Public Library of Science | ||||||
ISSN: | 1932-6203 | ||||||
Official Date: | February 2011 | ||||||
Dates: |
|
||||||
Volume: | 6 | ||||||
Number: | 2 | ||||||
Article Number: | e17254 | ||||||
DOI: | 10.1371/journal.pone.0017254 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 10 October 2016 | ||||||
Date of first compliant Open Access: | 12 October 2016 | ||||||
Funder: | Royal Society (Great Britain), Magdalen College (University of Oxford) |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year