Parker, Alexander S., Al Botros, Rehab, Kinnear, Sophie L., Snowden, Michael E., McKelvey, Kim M. (Kim Martin), Ashcroft, Alexander T., Carvell, Mel, Joiner, Andrew, Peruffo, Massimo, Philpotts, Carol and Unwin, Patrick R. (2016) Combinatorial localized dissolution analysis : application to acid-induced dissolution of dental enamel and the effect of surface treatments. Journal of Colloid and Interface Science, 476 . pp. 94-102. doi:10.1016/j.jcis.2016.05.018

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Abstract

A combination of scanning electrochemical cell microscopy (SECCM) and atomic force microscopy (AFM) is used to quantitatively study the acid-induced dissolution of dental enamel. A micron-scale liquid meniscus formed at the end of a dual barrelled pipette, which constitutes the SECCM probe, is brought into contact with the enamel surface for a defined period. Dissolution occurs at the interface of the meniscus and the enamel surface, under conditions of well-defined mass transport, creating etch pits that are then analysed via AFM. This technique is applied to bovine dental enamel, and the effect of various treatments of the enamel surface on acid dissolution (1 mM HNO3) is studied. The treatments investigated are zinc ions, fluoride ions and the two combined. A finite element method (FEM) simulation of SECCM mass transport and interfacial reactivity, allows the intrinsic rate constant for acid-induced dissolution to be quantitatively determined. The dissolution of enamel, in terms of Ca2+ flux (jCa2+), is first order with respect to the interfacial proton concentration and given by the following rate law: jCa2+=k0[H+], with k0=0.099±0.008 cm s−1. Treating the enamel with either fluoride or zinc ions slows the dissolution rate, although in this model system the partly protective barrier only extends around 10–20 nm into the enamel surface, so that after a period of a few seconds dissolution of modified surfaces tends towards that of native enamel. A combination of both treatments exhibits the greatest protection to the enamel surface, but the effect is again transient.

Item Type:	Journal Article
Subjects:	R Medicine > RK Dentistry
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	Dentistry , Dental enamel, Cattle , Zinc ions , Fluorides
Journal or Publication Title:	Journal of Colloid and Interface Science
Publisher:	Academic Press Inc. Elsivier Science
ISSN:	0021-9797
Official Date:	15 August 2016
Dates:	Date Event 15 August 2016 Published 13 May 2016 Available 12 May 2016 Accepted 10 April 2016 Submitted
Date of first compliant deposit:	15 September 2016
Volume:	476
Page Range:	pp. 94-102
DOI:	10.1016/j.jcis.2016.05.018
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Engineering and Physical Sciences Research Council (EPSRC), Unilever (Firm), Seventh Framework Programme (European Commission) (FP7), Advantage West Midlands (AWM), Birmingham Science City, European Regional Development Fund (ERDF)
Grant number:	(FP7/2007-2013)/ERC, 2009-AdG2471143-QUANTIF
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