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Sequence-controlled methacrylic multiblock copolymers via sulfur-free RAFT emulsion polymerization
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Engelis, Nikolaos, Anastasaki, Athina, Nurumbetov, Gabit, Truong, Nghia P., Nikolaou, Vasiliki, Shegiwal, Ataulla, Whittaker, Michael R., Davis, Thomas P. and Haddleton, David M. (2016) Sequence-controlled methacrylic multiblock copolymers via sulfur-free RAFT emulsion polymerization. Nature Chemistry, 9 . pp. 171-178. doi:10.1038/nchem.2634
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Official URL: http://dx.doi.org/10.1038/nchem.2634
Abstract
Translating the precise monomer sequence control achieved in nature over macromolecular structure (for example, DNA) to whole synthetic systems has been limited due to the lack of efficient synthetic methodologies. So far, chemists have only been able to synthesize monomer sequence-controlled macromolecules by means of complex, time-consuming and iterative chemical strategies such as solid-state Merrifield-type approaches or molecularly dissolved solution-phase systems. Here, we report a rapid and quantitative synthesis of sequence-controlled multiblock polymers in discrete stable nanoscale compartments via an emulsion polymerization approach in which a vinyl-terminated macromolecule is used as an efficient chain-transfer agent. This approach is environmentally friendly, fully translatable to industry and thus represents a significant advance in the development of complex macromolecule synthesis, where a high level of molecular precision or monomer sequence control confers potential for molecular targeting, recognition and biocatalysis, as well as molecular information storage.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry | ||||||||
| Divisions: | Faculty of Science > Chemistry | ||||||||
| Library of Congress Subject Headings (LCSH): | Macromolecules -- Synthesis, Monomers, Polymers, Fragmentation reactions | ||||||||
| Journal or Publication Title: | Nature Chemistry | ||||||||
| Publisher: | Nature Publishing Group | ||||||||
| ISSN: | 1755-4330 | ||||||||
| Official Date: | 17 October 2016 | ||||||||
| Dates: |
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| Date of first compliant deposit: | 19 October 2016 | ||||||||
| Volume: | 9 | ||||||||
| Page Range: | pp. 171-178 | ||||||||
| DOI: | 10.1038/nchem.2634 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Funder: | University of Warwick, Australian Research Council (ARC). Centre of Excellence in Convergent Bio-Nano Science and Technology, Royal Society (Great Britain). Wolfson Research Merit Award (RSWRMA) | ||||||||
| Grant number: | CE140100036 (ARC) | ||||||||
| Adapted As: |
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