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Sequence-controlled methacrylic multiblock copolymers via sulfur-free RAFT emulsion polymerization

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Engelis, Nikolaos, Anastasaki, Athina, Nurumbetov, Gabit, Truong, Nghia P., Nikolaou, Vasiliki, Shegiwal, Ataulla, Whittaker, Michael R., Davis, Thomas P. and Haddleton, David M. (2016) Sequence-controlled methacrylic multiblock copolymers via sulfur-free RAFT emulsion polymerization. Nature Chemistry, 9 . pp. 171-178. doi:10.1038/nchem.2634 ISSN 1755-4330.

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Official URL: http://dx.doi.org/10.1038/nchem.2634

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Abstract

Translating the precise monomer sequence control achieved in nature over macromolecular structure (for example, DNA) to whole synthetic systems has been limited due to the lack of efficient synthetic methodologies. So far, chemists have only been able to synthesize monomer sequence-controlled macromolecules by means of complex, time-consuming and iterative chemical strategies such as solid-state Merrifield-type approaches or molecularly dissolved solution-phase systems. Here, we report a rapid and quantitative synthesis of sequence-controlled multiblock polymers in discrete stable nanoscale compartments via an emulsion polymerization approach in which a vinyl-terminated macromolecule is used as an efficient chain-transfer agent. This approach is environmentally friendly, fully translatable to industry and thus represents a significant advance in the development of complex macromolecule synthesis, where a high level of molecular precision or monomer sequence control confers potential for molecular targeting, recognition and biocatalysis, as well as molecular information storage.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Library of Congress Subject Headings (LCSH): Macromolecules -- Synthesis, Monomers, Polymers, Fragmentation reactions
Journal or Publication Title: Nature Chemistry
Publisher: Nature Publishing Group
ISSN: 1755-4330
Official Date: 17 October 2016
Dates:
DateEvent
17 October 2016Published
2 September 2016Accepted
22 February 2016Submitted
Volume: 9
Page Range: pp. 171-178
DOI: 10.1038/nchem.2634
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 19 October 2016
Date of first compliant Open Access: 17 April 2017
Funder: University of Warwick, Australian Research Council (ARC). Centre of Excellence in Convergent Bio-Nano Science and Technology, Royal Society (Great Britain). Wolfson Research Merit Award (RSWRMA)
Grant number: CE140100036 (ARC)
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