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Summary of glaucoma diagnostic testing accuracy : an evidence-based meta-analysis

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Ahmed, Saad, Khan, Zainab, Si, Francie, Mao, Alex, Pan, Irene, Yazdi, Fatemeh, Tsertsvadze, Alexander, Hutnik, Cindy, Moher, David, Tingey, David, Trope, Graham E., Damji, Karim F., Tarride, Jean-Eric, Goeree, Ron and Hodge, William (2016) Summary of glaucoma diagnostic testing accuracy : an evidence-based meta-analysis. Journal of Clinical Medicine Research, 8 (9). pp. 641-649. doi:10.14740/jocmr2643w ISSN 1918-3003.

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Official URL: http://dx.doi.org/10.14740/jocmr2643w

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Abstract

Background: New glaucoma diagnostic technologies are penetrating clinical care and are changing rapidly. Having a systematic review of these technologies will help clinicians and decision makers and help identify gaps that need to be addressed. This systematic review studied five glaucoma technologies compared to the gold standard of white on white perimetry for glaucoma detection.

Methods: OVID® interface: MEDLINE® (In-Process & Other Non-Indexed Citations), EMBASE®, BIOSIS Previews®, CINAHL®, PubMed, and the Cochrane Library were searched. A gray literature search was also performed. A technical expert panel, information specialists, systematic review method experts and biostatisticians were used. A PRISMA flow diagram was created and a random effect meta-analysis was performed.

Results: A total of 2,474 articles were screened. The greatest accuracy was found with frequency doubling technology (FDT) (diagnostic odds ratio (DOR): 57.7) followed by blue on yellow perimetry (DOR: 46.7), optical coherence tomography (OCT) (DOR: 41.8), GDx (DOR: 32.4) and Heidelberg retina tomography (HRT) (DOR: 17.8). Of greatest concern is that tests for heterogeneity were all above 50%, indicating that cutoffs used in these newer technologies were all very varied and not uniform across studies.

Conclusions: Glaucoma content experts need to establish uniform cutoffs for these newer technologies, so that studies that compare these technologies can be interpreted more uniformly. Nevertheless, synthesized data at this time demonstrate that amongst the newest technologies, OCT has the highest glaucoma diagnostic accuracy followed by GDx and then HRT

Item Type: Journal Article
Subjects: R Medicine > R Medicine (General)
R Medicine > RE Ophthalmology
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Glaucoma -- Diagnosis, Systematic reviews (Medical research)
Journal or Publication Title: Journal of Clinical Medicine Research
Publisher: Elmer Press Inc.
ISSN: 1918-3003
Official Date: 2016
Dates:
DateEvent
2016Published
13 July 2016Accepted
Volume: 8
Number: 9
Page Range: pp. 641-649
DOI: 10.14740/jocmr2643w
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 8 November 2016
Date of first compliant Open Access: 8 November 2016
Funder: Canadian Institutes of Health Research (CIHR)
Grant number: #KRS 91789

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