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Summary of glaucoma diagnostic testing accuracy : an evidence-based meta-analysis
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Ahmed, Saad, Khan, Zainab, Si, Francie, Mao, Alex, Pan, Irene, Yazdi, Fatemeh, Tsertsvadze, Alexander, Hutnik, Cindy, Moher, David, Tingey, David, Trope, Graham E., Damji, Karim F., Tarride, Jean-Eric, Goeree, Ron and Hodge, William (2016) Summary of glaucoma diagnostic testing accuracy : an evidence-based meta-analysis. Journal of Clinical Medicine Research, 8 (9). pp. 641-649. doi:doi:10.14740/jocmr2643w
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Official URL: http://dx.doi.org/10.14740/jocmr2643w
Abstract
Background: New glaucoma diagnostic technologies are penetrating clinical care and are changing rapidly. Having a systematic review of these technologies will help clinicians and decision makers and help identify gaps that need to be addressed. This systematic review studied five glaucoma technologies compared to the gold standard of white on white perimetry for glaucoma detection.
Methods: OVID® interface: MEDLINE® (In-Process & Other Non-Indexed Citations), EMBASE®, BIOSIS Previews®, CINAHL®, PubMed, and the Cochrane Library were searched. A gray literature search was also performed. A technical expert panel, information specialists, systematic review method experts and biostatisticians were used. A PRISMA flow diagram was created and a random effect meta-analysis was performed.
Results: A total of 2,474 articles were screened. The greatest accuracy was found with frequency doubling technology (FDT) (diagnostic odds ratio (DOR): 57.7) followed by blue on yellow perimetry (DOR: 46.7), optical coherence tomography (OCT) (DOR: 41.8), GDx (DOR: 32.4) and Heidelberg retina tomography (HRT) (DOR: 17.8). Of greatest concern is that tests for heterogeneity were all above 50%, indicating that cutoffs used in these newer technologies were all very varied and not uniform across studies.
Conclusions: Glaucoma content experts need to establish uniform cutoffs for these newer technologies, so that studies that compare these technologies can be interpreted more uniformly. Nevertheless, synthesized data at this time demonstrate that amongst the newest technologies, OCT has the highest glaucoma diagnostic accuracy followed by GDx and then HRT
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > R Medicine (General) R Medicine > RE Ophthalmology |
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| Divisions: | Faculty of Medicine > Warwick Medical School | ||||||
| Library of Congress Subject Headings (LCSH): | Glaucoma -- Diagnosis, Systematic reviews (Medical research) | ||||||
| Journal or Publication Title: | Journal of Clinical Medicine Research | ||||||
| Publisher: | Elmer Press Inc. | ||||||
| ISSN: | 1918-3003 | ||||||
| Official Date: | 2016 | ||||||
| Dates: |
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| Date of first compliant deposit: | 8 November 2016 | ||||||
| Date of first compliant Open Access: | 8 November 2016 | ||||||
| Volume: | 8 | ||||||
| Number: | 9 | ||||||
| Page Range: | pp. 641-649 | ||||||
| DOI: | doi:10.14740/jocmr2643w | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access | ||||||
| Funder: | Canadian Institutes of Health Research (CIHR) | ||||||
| Grant number: | #KRS 91789 |
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