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Synthesis of mannosylated and PEGylated nanoparticles via RAFT emulsion polymerisation, and investigation of particle-lectin aggregation using turbidimetric and DLS techniques
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Gurnani, Pratik, Lunn, Andrew M. and Perrier, Sébastien (2016) Synthesis of mannosylated and PEGylated nanoparticles via RAFT emulsion polymerisation, and investigation of particle-lectin aggregation using turbidimetric and DLS techniques. Polymer, 106 . pp. 229-237. doi:10.1016/j.polymer.2016.08.093 ISSN 0032-3861.
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Official URL: http://dx.doi.org/10.1016/j.polymer.2016.08.093
Abstract
Recent developments in controlled radical polymerisation presents an attractive way of producing biocompatible polymeric nanoparticles for a wide range of applications. With this motivation, well defined P (ManAm) and P(PEGA) coated nanoparticles in a range of different sizes have been synthesised via RAFT emulsion polymerisation. The particles were used to precisely investigate the effect of particle size on lectin binding with Concanavalin A, and validate the use of online DLS measurements for lectin-glycoparticle aggregation studies. Larger particles were found to have an enhanced aggregation by both UV–Vis turbidimetric and DLS aggregation studies. The DLS technique was shown to be robust up to an aggregate diameter of c.500 nm for aggregation tests, and was not affected by any dilution or light scattering effects that typically hinder the common use of turbidimetry in particle aggregation studies.
Item Type: | Journal Article | ||||||||||
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Subjects: | Q Science > QD Chemistry Q Science > QP Physiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||
Library of Congress Subject Headings (LCSH): | Colloids, Lectins, Polymers -- Synthesis, Emulsion polymerization, Fragmentation reactions | ||||||||||
Journal or Publication Title: | Polymer | ||||||||||
Publisher: | Elsevier Science BV | ||||||||||
ISSN: | 0032-3861 | ||||||||||
Official Date: | 5 December 2016 | ||||||||||
Dates: |
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Volume: | 106 | ||||||||||
Page Range: | pp. 229-237 | ||||||||||
DOI: | 10.1016/j.polymer.2016.08.093 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||
Date of first compliant deposit: | 14 November 2016 | ||||||||||
Date of first compliant Open Access: | 31 August 2017 | ||||||||||
Funder: | Royal Society (Great Britain). Wolfson Research Merit Award (RSWRMA), Monash-Warwick Alliance | ||||||||||
Grant number: | WM130055 (RSWRMA) |
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