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Preparation of inert polystyrene latex particles as microRNA delivery vectors by surfactant-free RAFT emulsion polymerization
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Poon, Cheuk Ka, Tang, Owen, Chen, Xin-Ming, Pham, Binh T. T., Gody, Guillaume, Pollock, Carol A., Hawkett, Brian S. and Perrier, Sébastien (2016) Preparation of inert polystyrene latex particles as microRNA delivery vectors by surfactant-free RAFT emulsion polymerization. Biomacromolecules, 17 (3). pp. 965-973. doi:10.1021/acs.biomac.5b01633 ISSN 1525-7797.
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Official URL: http://dx.doi.org/10.1021/acs.biomac.5b01633
Abstract
We present the preparation of 11 nm polyacrylamide-stabilized polystyrene latex particles for conjugation to a microRNA model by surfactant-free RAFT emulsion polymerization. Our synthetic strategy involved the preparation of amphiphilic polyacrylamide-block-polystyrene copolymers, which were able to self-assemble into polymeric micelles and “grow” into polystyrene latex particles. The surface of these sterically stabilized particles was postmodified with a disulfide-bearing linker for the attachment of the microRNA model, which can be released from the latex particles under reducing conditions. These nanoparticles offer the advantage of ease of preparation via a scaleable process, and the versatility of their synthesis makes them adaptable to a range of applications.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QD Chemistry T Technology > TP Chemical technology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
Library of Congress Subject Headings (LCSH): | Polystyrene, Latex, Addition polymerization, Block copolymers, Fragmentation reactions | ||||||||
Journal or Publication Title: | Biomacromolecules | ||||||||
Publisher: | American Chemical Society | ||||||||
ISSN: | 1525-7797 | ||||||||
Official Date: | 25 January 2016 | ||||||||
Dates: |
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Volume: | 17 | ||||||||
Number: | 3 | ||||||||
Page Range: | pp. 965-973 | ||||||||
DOI: | 10.1021/acs.biomac.5b01633 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 15 November 2016 | ||||||||
Date of first compliant Open Access: | 25 January 2017 | ||||||||
Funder: | University of Sydney, Royal Society (Great Britain). Wolfson Research Merit Award (RSWRMA), Monash-Warwick Alliance | ||||||||
Grant number: | WM130055 (RSWRMA) |
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