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5-aminolevulinic acid–protoporphyrin IX fluorescence-guided surgery of high-grade gliomas : a systematic review
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Guyotat, Jacques, Pallud, Johan, Armoiry, Xavier, Pavlov, Vladislav and Metellus, Philippe (2016) 5-aminolevulinic acid–protoporphyrin IX fluorescence-guided surgery of high-grade gliomas : a systematic review. In: Schramm, Johannes, (ed.) Advances and Technical Standards in Neurosurgery. Advances and technical standards in neurosurgery, 43 . Cham, Switzerland: Springer, pp. 61-90. ISBN 9783319213590
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Official URL: http://dx.doi.org/10.1007/978-3-319-21359-0_3
Abstract
The current first-line treatment of malignant gliomas consists in surgical resection (if possible) as large as possible. The existing tools don’t permit to identify the limits of tumor infiltration, which goes beyond the zone of contrast enhancement on MRI. The fluorescence-guided malignant gliomas surgery was started 15 years ago and had become a standard of care in many countries. The technique is based on fluorescent molecule revelation using the filters, positioned within the surgical microscope. The fluorophore, protoporphyrin IX (PpIX), is converted in tumoral cells from 5-aminolevulinic acid (5-ALA), given orally before surgery. Many studies have shown that the ratio of gross total resections was higher if the fluorescence technique was used. The fluorescence signal intensity is correlated to the cell density and the PpIX concentration. The current method has a very high specificity but still lower sensibility, particularly regarding the zones with poor tumoral infiltration. This book reviews the principles of the technique and the results (extent of resection and survival).
Item Type: | Book Item | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Series Name: | Advances and technical standards in neurosurgery | ||||
Publisher: | Springer | ||||
Place of Publication: | Cham, Switzerland | ||||
ISBN: | 9783319213590 | ||||
ISSN: | 0095-4829 | ||||
Book Title: | Advances and Technical Standards in Neurosurgery | ||||
Editor: | Schramm, Johannes | ||||
Official Date: | 2016 | ||||
Dates: |
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Volume: | 43 | ||||
Number of Pages: | 239 | ||||
Page Range: | pp. 61-90 | ||||
DOI: | 10.1007/978-3-319-21359-0_3 | ||||
Status: | Not Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
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