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Mixed micelles loaded with bile salt : an approach to enhance intestinal transport of the BCS class III drug cefotaxime in rats
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Arafat, Mosab, Kirchhoefer, Cathrin and Mikov, Momir (2016) Mixed micelles loaded with bile salt : an approach to enhance intestinal transport of the BCS class III drug cefotaxime in rats. European Journal of Drug Metabolism and Pharmacokinetics . doi:10.1007/s13318-016-0375-9 ISSN 0378-7966.
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Official URL: http://dx.doi.org/10.1007/s13318-016-0375-9
Abstract
Cefotaxime is a class III drug according to the Biopharmaceutical Classification System due to low intestinal permeability based on poor oral bioavailability. Bile salt compounds have been shown to be effective additive for drug permeation through several biological membranes. The main purpose of this study was to investigate the ability of a mixed micelles made of phosphatidylcholine, sodium deoxycholate, and loaded with a cefotaxime-3α,7α-dihydroxy-12-keto-5β-cholanate complex to enhance the oral bioavailability of cefotaxime in rats.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Journal or Publication Title: | European Journal of Drug Metabolism and Pharmacokinetics | ||||
Publisher: | Springer | ||||
ISSN: | 0378-7966 | ||||
Official Date: | 29 September 2016 | ||||
Dates: |
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DOI: | 10.1007/s13318-016-0375-9 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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