The Library
Fluorescent polymeric nanovehicles for neural stem cell modulation
Tools
Tools
Tools
Papadimitriou, S. A., Robin, Mathew P., Ceric, D., O'Reilly, Rachel K., Marino, S. and Resmini, M. (2016) Fluorescent polymeric nanovehicles for neural stem cell modulation. Nanoscale, 8 (39). pp. 17340-17349. doi:10.1039/c6nr06440j ISSN 2040-3364.
|
PDF
WRAP_c6nr06440j.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution. Download (4Mb) | Preview |
Official URL: http://dx.doi.org/10.1039/c6nr06440j
Abstract
Nanomaterials are emerging as strong candidates for applications in drug delivery and offer an alternative platform to modulate the differentiation and activity of neural stem cells. Herein we report the synthesis and characterization of two different classes of polymeric nanoparticles: N-isopropylacrylamide-based thermoresponsive nanogels RM1 and P(TEGA)-b-P(D,LLA)2 nano-micelles RM2. We covalently linked the nanoparticles with fluorescent tags and demonstrate their ability to be internalized and tracked in neural stem cells from the postnatal subventricular zone, without affecting their proliferation, multipotency and differentiation characteristics up to 150 μg ml−1. The difference in chemical structure of RM1 and RM2 does not appear to impact toxicity however it influences the loading capacity. Nanogels RM1 loaded with retinoic acid improve solubility of the drug which is released at 37 °C, resulting in an increase in the number of neurons, comparable to what can be obtained with a solution of the free drug solubilised with a small percentage of DMSO.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica T Technology > TP Chemical technology |
||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
| Library of Congress Subject Headings (LCSH): | Polymeric drug delivery systems, Nanoparticles, Neural stem cells, Nanogels, Thermoresponsive polymers | ||||||||
| Journal or Publication Title: | Nanoscale | ||||||||
| Publisher: | Royal Society of Chemistry | ||||||||
| ISSN: | 2040-3364 | ||||||||
| Official Date: | 27 September 2016 | ||||||||
| Dates: |
|
||||||||
| Volume: | 8 | ||||||||
| Number: | 39 | ||||||||
| Page Range: | pp. 17340-17349 | ||||||||
| DOI: | 10.1039/c6nr06440j | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 27 February 2017 | ||||||||
| Date of first compliant Open Access: | 27 February 2017 | ||||||||
| Funder: | Marie Skłodowska-Curie actions, Engineering and Physical Sciences Research Council (EPSRC), Ataxia UK | ||||||||
| Grant number: | Grant agreement 329207 (Marie Skłodowska-Curie actions), Grant no. EP/K503411/1 (EPSRC) |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
