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Integrated predictive genome-scale models to improve the metabolic re-engineering efficiency
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Kulkarni, Vishwesh V., El Menjra, Lina, Carbonell, Pablo and Faulon, Jean-Loup (2016) Integrated predictive genome-scale models to improve the metabolic re-engineering efficiency. In: 8th International Workshop on Bio-Design Automation, Newcastle-upon-Tyne, UK, 16-18 Aug 2016
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WRAP_bioretrosynthprome-IWBDA2016abstract.pdf - Accepted Version - Requires a PDF viewer. Download (504Kb) |
Official URL: http://www.iwbdaconf.org/2016/
Abstract
One of the most common applications of metabolic circuits is to produce a desired chemical in a chassis organism, such as the Escherichia coli (E. coli), by importing heterologous genes encoding for the enzymes that participate in the biosynthetic pathway. Recently, an automated pipeline named RetroPath was developed to synthesise embedded metabolic circuits [1]. These circuits are to be embedded in E. coli for a wide range of applications such as regulating biomass productions, sensing specifc molecules, processing specific molecules, and releasing specific molecules. In this paper, we improve the efficiency of RetroPath via quadratic programming.
Item Type: | Conference Item (Speech) | ||||||||
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Subjects: | Q Science > QP Physiology Q Science > QR Microbiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||||
Library of Congress Subject Headings (LCSH): | Escherichia coli, Biosynthesis | ||||||||
Official Date: | 18 August 2016 | ||||||||
Dates: |
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Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Date of first compliant deposit: | 1 December 2016 | ||||||||
Date of first compliant Open Access: | 1 December 2016 | ||||||||
Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC) | ||||||||
Grant number: | BB/M017702/1 | ||||||||
Conference Paper Type: | Speech | ||||||||
Title of Event: | 8th International Workshop on Bio-Design Automation | ||||||||
Type of Event: | Workshop | ||||||||
Location of Event: | Newcastle-upon-Tyne, UK | ||||||||
Date(s) of Event: | 16-18 Aug 2016 | ||||||||
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