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Identification of a plant gene encoding glutamate/aspartate-prephenate aminotransferase : the last homeless enzyme of aromatic amino acids biosynthesis
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Graindorge, Matthieu, Giustini, Cécile, Jacomin, Anne-Claire, Kraut, Alexandra, Curien, Gilles and Matringe, Michel (2010) Identification of a plant gene encoding glutamate/aspartate-prephenate aminotransferase : the last homeless enzyme of aromatic amino acids biosynthesis. FEBS Letters, 584 (20). pp. 4357-4360. doi:10.1016/j.febslet.2010.09.037 ISSN 0014-5793.
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Official URL: http://dx.doi.org/10.1016/j.febslet.2010.09.037
Abstract
In all organisms synthesising phenylalanine and/or tyrosine via arogenate, a prephenate aminotransferase is required for the transamination of prephenate into arogenate. The identity of the gene encoding this enzyme in the organisms where this activity occurs is still unknown. Glutamate/aspartate-prephenate aminotransferase (PAT) is thus the last homeless enzyme in the aromatic amino acids pathway. We report on the purification, mass spectrometry identification and biochemical characterization of Arabidopsis thaliana prephenate aminotransferase. Our data revealed that this activity is housed by the prokaryotic-type plastidic aspartate aminotransferase (At2g22250). This represents the first identification of a gene encoding PAT.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QH Natural history > QH301 Biology | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
Journal or Publication Title: | FEBS Letters | ||||||||
Publisher: | Elsevier BV | ||||||||
ISSN: | 0014-5793 | ||||||||
Official Date: | 22 October 2010 | ||||||||
Dates: |
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Volume: | 584 | ||||||||
Number: | 20 | ||||||||
Page Range: | pp. 4357-4360 | ||||||||
DOI: | 10.1016/j.febslet.2010.09.037 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) |
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