The Library
Wrist actimetry circadian rhythm as a robust predictor of colorectal cancer patients survival
Tools
Lévi, Francis A., Dugué, Pierre-Antoine, Innominato, Pasquale F., Karaboué, Abdoulaye, Dispersyn, Garance, Parganiha, Arti, Giacchetti, Sylvie, Moreau, Thierry, Focan, Christian, Waterhouse, Jim and Spiegel, David (2014) Wrist actimetry circadian rhythm as a robust predictor of colorectal cancer patients survival. Chronobiology International, 31 (8). pp. 891-900. doi:10.3109/07420528.2014.924523 ISSN 0742-0528.
PDF
WRAP_wms_transexp_med-130117-chronobiol_int_revise.pdf - Accepted Version - Requires a PDF viewer. Download (1380Kb) |
Official URL: http://dx.doi.org/10.3109/07420528.2014.924523
Abstract
The disruption of the circadian timing system (CTS), which rhythmically controls cellular metabolism and proliferation, accelerated experimental cancer progression. A measure of CTS function in cancer patients could thus provide novel prediction information for outcomes, and help to identify novel specific therapies. The rest-activity circadian rhythm is a reliable and non-invasive CTS biomarker, which was monitored using a wrist watch accelerometer for 2 days in 436 patients with metastatic colorectal cancer. The relative percentage of activity in-bed versus out-of-bed (I < O) constituted the tested CTS measure, whose prognostic value for overall survival (OS) and progression-free survival (PFS) was determined in a pooled analysis of three patient cohorts with different treatment exposures. Median OS was 21.6 months [17.8–25.5] for patients with I < O above the median value of 97.5% as compared to 11.9 months [10.4–13.3] for those with a lower I < O (Log-rank p < 0.001). Multivariate analyses retained continuous I < O as a joint predictor of both OS and PFS, with respective hazard ratios (HR) of 0.954 (p < 0.001) and 0.970 (p < 0.001) for each 1% increase in I < O. HRs had similar values in all the patient subgroups tested. The circadian physiology biomarker I < O constitutes a robust and independent quantitative predictor of cancer patient outcomes, that can be easily and cost-effectively measured during daily living. Interventional studies involving 24-h schedules of clock-targeted drugs, light intensity, exercise and/or meals are needed for testing the relevance of circadian synchronization for the survival of patients with disrupted rhythms.
Item Type: | Journal Article | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Subjects: | Q Science > QH Natural history R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
|||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
|||||||||||||||
Library of Congress Subject Headings (LCSH): | Rectum -- Cancer -- Treatment, Colon (Anatomy) -- Cancer -- Treatment, Circadian rhythms, Cancer -- Patients, Medical technology, Biochemical markers, Cell metabolism, Cell proliferation, Metastasis | |||||||||||||||
Journal or Publication Title: | Chronobiology International | |||||||||||||||
Publisher: | Informa Healthcare | |||||||||||||||
ISSN: | 0742-0528 | |||||||||||||||
Official Date: | 13 June 2014 | |||||||||||||||
Dates: |
|
|||||||||||||||
Volume: | 31 | |||||||||||||||
Number: | 8 | |||||||||||||||
Page Range: | pp. 891-900 | |||||||||||||||
DOI: | 10.3109/07420528.2014.924523 | |||||||||||||||
Status: | Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||
Date of first compliant deposit: | 17 January 2017 | |||||||||||||||
Date of first compliant Open Access: | 17 January 2017 | |||||||||||||||
RIOXX Funder/Project Grant: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year