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Design of an embedded inverse-feedforward biomolecular tracking controller for enzymatic reaction processes
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Foo, Mathias, Kim, Jongrae, Sawlekar, Rucha and Bates, Declan (2017) Design of an embedded inverse-feedforward biomolecular tracking controller for enzymatic reaction processes. Computers & Chemical Engineering, 99 . pp. 145-157. doi:10.1016/j.compchemeng.2017.01.027 ISSN 0098-1354.
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Official URL: http://dx.doi.org/10.1016/j.compchemeng.2017.01.02...
Abstract
Feedback control is widely used in chemical engineering to improve the performance and robustness of chemical processes. Feedback controllers require a ‘subtractor’ that is able to compute the error between the process output and the reference signal. In the case of embedded biomolecular control circuits, subtractors designed using standard chemical reaction network theory can only realise one-sided subtraction, rendering standard controller design approaches inadequate. Here, we show how a biomolecular controller that allows tracking of required changes in the outputs of enzymatic reaction processes can be designed and implemented within the framework of chemical reaction network theory. The controller architecture employs an inversion-based feedforward controller that compensates for the limitations of the one-sided subtractor that generates the error signals for a feedback controller. The proposed approach requires significantly fewer chemical reactions to implement than alternative designs, and should have wide applicability throughout the fields of synthetic biology and biological engineering.
Item Type: | Journal Article | ||||||||||
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Subjects: | T Technology > TP Chemical technology | ||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||||||
Library of Congress Subject Headings (LCSH): | Feedforward control systems, Chemical engineering, Enzymes, Bioengineering, Process control, Synthetic biology | ||||||||||
Journal or Publication Title: | Computers & Chemical Engineering | ||||||||||
Publisher: | Pergamon | ||||||||||
ISSN: | 0098-1354 | ||||||||||
Official Date: | 6 April 2017 | ||||||||||
Dates: |
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Volume: | 99 | ||||||||||
Page Range: | pp. 145-157 | ||||||||||
DOI: | 10.1016/j.compchemeng.2017.01.027 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
Date of first compliant deposit: | 19 January 2017 | ||||||||||
Date of first compliant Open Access: | 19 January 2017 | ||||||||||
Funder: | Engineering and Physical Sciences Research Council (EPSRC), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), University of Warwick. Department of Engineering | ||||||||||
Grant number: | BB/M017982/1 (BBSRC) |
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