Alfred Witjes, J., Lebret, Thierry, Compérat, Eva M., Cowan, Nigel C., De Santis, Maria , Bruins, Harman Maxim, Hernández, Virginia, Espinós, Estefania Linares, Dunn, James, Rouanne, Mathieu, Neuzillet, Yann, Veskimäe, Erik, van der Heijden, Antoine G., Gakis, Georgios and Ribal, Maria J. (2017) Updated 2016 EAU guidelines on muscle-invasive and metastatic bladder cancer. European Urology, 71 (3). doi:10.1016/j.eururo.2016.06.020 ISSN 0302-2838.
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Abstract
Context:
Invasive bladder cancer is a frequently occurring disease with a high mortality rate despite optimal treatment. The European Association of Urology (EAU) Muscle-invasive and Metastatic Bladder Cancer (MIBC) Guidelines are updated yearly and provides information to optimise diagnosis, treatment, and follow-up of this patient population.
Objective:
To provide a summary of the EAU guidelines for physicians and patients confronted with muscle-invasive and metastatic bladder cancer.
Evidence acquisition:
An international multidisciplinary panel of bladder cancer experts reviewed and discussed the results of a comprehensive literature search of several databases covering all sections of the guidelines. The panel defined levels of evidence and grades of recommendation according to an established classification system.
Evidence synthesis:
Epidemiology and aetiology of bladder cancer are discussed. The proper diagnostic pathway, including demands for pathology and imaging, is outlined. Several treatment options, including bladder-sparing treatments and combinations of treatment modalities (different forms of surgery, radiation therapy, and chemotherapy) are described. Sequencing of these modalities is discussed. Potential indications and contraindications, such as comorbidity, are related to treatment choice. There is a new paragraph on organ-sparing approaches, both in men and in women, and on minimal invasive surgery. Recommendations for chemotherapy in fit and unfit patients are provided including second-line options. Finally, a follow-up schedule is provided.
Conclusions:
The current summary of the EAU Muscle-invasive and Metastatic Bladder Cancer Guidelines provides an up-to-date overview of the available literature and evidence dealing with diagnosis, treatment, and follow-up of patients with metastatic and muscle-invasive bladder cancer.
Patient summary:
Bladder cancer is an important disease with a high mortality rate. These updated guidelines help clinicians refine the diagnosis and select the appropriate therapy and follow-up for patients with metastatic and muscle-invasive bladder cancer.
| Item Type: | Journal Article |
|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
| Journal or Publication Title: | European Urology |
| Publisher: | Elsevier BV |
| ISSN: | 0302-2838 |
| Official Date: | March 2017 |
| Dates: | Date Event March 2017 Published 30 June 2016 Available 13 June 2016 Accepted |
| Volume: | 71 |
| Number: | 3 |
| DOI: | 10.1016/j.eururo.2016.06.020 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | https://wrap.warwick.ac.uk/85201/ |
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