The Library
Role of small-molecule modifiers in replication initiation
Tools
De Piccoli, Giacomo and Gambus, Agnieszka (2016) Role of small-molecule modifiers in replication initiation. In: Kaplan, D. L., (ed.) The Initiation of DNA Replication in Eukaryotes. Cham, Switzerland: Springer International Publishing, pp. 343-370. ISBN 9783319246963
Microsoft Word
chapter 17ii.doc Embargoed item. Restricted access to Repository staff only Download (895Kb) |
Official URL: http://dx.doi.org/10.1007/978-3-319-24696-3_17
Abstract
Post-translational modification of proteins through attachment of ubiquitin or ubiquitin-like proteins (UBLs) changes the three-dimensional structure of the modified factors and affects their activity, interactions and turnover. Ubiquitin and UBLs constitute a very versatile and flexible system of protein modification and regulate almost every aspect of cell biology. In this chapter we focus on the role of these small protein modifiers in regulation of DNA replication initiation. We will review the accumulated knowledge showing how ubiquitin-driven proteasomal degradation leads to creation of sequential, non-overlapping stages of the cell cycle allowing DNA replication initiation and how it prevents re-replication during S-phase. We will also explain the role ubiquitylation plays in the inhibition of DNA replication initiation in response to DNA damage. As the regulation of replication factors is often executed through modifications with both small protein modifiers and phosphorylation - we will also discuss the important crossovers between these two regulatory mechanisms. Finally, we will review our present knowledge of regulation of DNA replication initiation by non-degradative forms of ubiquitylation and modifications with Nedd8 and SUMO.
Item Type: | Book Item | ||||||
---|---|---|---|---|---|---|---|
Subjects: | Q Science > Q Science (General) | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences |
||||||
Publisher: | Springer International Publishing | ||||||
Place of Publication: | Cham, Switzerland | ||||||
ISBN: | 9783319246963 | ||||||
Book Title: | The Initiation of DNA Replication in Eukaryotes | ||||||
Editor: | Kaplan, D. L. | ||||||
Official Date: | 12 February 2016 | ||||||
Dates: |
|
||||||
Page Range: | pp. 343-370 | ||||||
DOI: | 10.1007/978-3-319-24696-3_17 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||
Copyright Holders: | Springer International Publishing Switzerland | ||||||
Funder: | Cancer Research UK (CRUK) | ||||||
Grant number: | C44595/A16326 | ||||||
Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |