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Fully biodegradable and biocompatible emulsion templated polymer scaffolds by thiol-acrylate polymerization of polycaprolactone macromonomers
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Johnson, D. W., Langford, C. R., Didsbury, M. P., Lipp, B., Przyborski, S. A. and Cameron, Neil R. (2015) Fully biodegradable and biocompatible emulsion templated polymer scaffolds by thiol-acrylate polymerization of polycaprolactone macromonomers. Polymer Chemistry, 6 (41). pp. 7256-7263. doi:10.1039/C5PY00721F ISSN 1759-9954.
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Official URL: http://dx.doi.org/10.1039/C5PY00721F
Abstract
The emulsion templating process offers a route to highly porous polymers with well-defined morphologies. This study describes the preparation of such porous polymers (polyHIPEs) via the photopolymerization of a multi-functional thiol and polycaprolactone macromonomer. The resulting materials have nominal porosities of 90% and 95%, and are seen to have an interconnected pore morphology, with an average pore diameter of approximately 60 μm. Initial biocompatibility assessments with fibroblast cells (L929) have shown that the polymers are capable of supporting cell growth over 7 days and degradation products are non-toxic to cells up to a concentration of 0.1 mg ml−1.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QD Chemistry T Technology > TP Chemical technology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||||
| Library of Congress Subject Headings (LCSH): | Porous materials , Emulsions, Photopolymerization, Thiols, Polycaprolactone, Fibroblasts | ||||||||
| Journal or Publication Title: | Polymer Chemistry | ||||||||
| Publisher: | Royal Society of Chemistry | ||||||||
| ISSN: | 1759-9954 | ||||||||
| Official Date: | 7 November 2015 | ||||||||
| Dates: |
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| Volume: | 6 | ||||||||
| Number: | 41 | ||||||||
| Page Range: | pp. 7256-7263 | ||||||||
| DOI: | 10.1039/C5PY00721F | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Date of first compliant deposit: | 19 January 2017 | ||||||||
| Date of first compliant Open Access: | 19 January 2017 | ||||||||
| Funder: | European Science Foundation (ESF), Seventh Framework Programme (European Commission) (FP7), Engineering and Physical Sciences Research Council (EPSRC), Erasmus Mundus (Program) | ||||||||
| Grant number: | FP7-‐SME-‐2008-‐2-‐243542-‐HIP (FP7) |
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