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Obesity-related metabolic and reproductive dysfunction : variations between the sexes
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Dimitriadis, Georgios K. and Barber, T. M. (2016) Obesity-related metabolic and reproductive dysfunction : variations between the sexes. Expert Review of Endocrinology & Metabolism, 11 (5). pp. 387-393. doi:10.1080/17446651.2016.1220301 ISSN 1744-6651.
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Official URL: http://dx.doi.org/10.1080/17446651.2016.1220301
Abstract
Introduction: Obesity prevalence remains at epidemic levels globally and is showing no signs of abating in either adult or child populations.
Areas covered: Obesity-associated metabolic and reproductive diseases appear to be sexually dimorphic. Polycystic Ovary Syndrome (PCOS) and male obesity-associated secondary (hypogonadotrophic) hypogonadism (MOSH) represent two of the most common obesity associated endocrinopathies with sex-specific metabo-reproductive aberrations. These two diseases have entirely separate pathogeneses, with characteristic sex-specific clinico-pathological findings. These differences result from effects of sex-specific hormones, including estrogens and androgens. Such differences in sex-hormones also influence patterns of body-fat distribution.
Expert commentary: This article focuses on sex-specific obesity-related metabolic and reproductive dysfunction. To illustrate key sex-related differences in the mechanisms by which obesity contributes towards metabolic and reproductive dysfunction, two common obesity-related conditions affecting women and men are considered: respectively, Polycystic Ovary Syndrome (PCOS) and Male Obesity-associated Secondary Hypogonadism (MOSH).
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Expert Review of Endocrinology & Metabolism | ||||||||
Publisher: | Taylor & Francis | ||||||||
ISSN: | 1744-6651 | ||||||||
Official Date: | 12 August 2016 | ||||||||
Dates: |
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Volume: | 11 | ||||||||
Number: | 5 | ||||||||
Page Range: | pp. 387-393 | ||||||||
DOI: | 10.1080/17446651.2016.1220301 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
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