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The dynamic architecture of the metabolic switch in Streptomyces coelicolor

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Nieselt, Kay, Battke, Florian, Herbig, Alexander, Bruheim, Per, Wentzel, Alexander, Jakobsen, Øyvind M, Sletta, Håvard, Alam, Mohammad Tauqee, Merlo, Maria E., Moore, Jonathan et al.
(2010) The dynamic architecture of the metabolic switch in Streptomyces coelicolor. BMC Genomics, 11 . p. 10. doi:DOI: 10.1186/1471-2164-11-10 ISSN 1471-2164.

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Official URL: http://dx.doi.org/10.1186/1471-2164-11-10

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Abstract

During the lifetime of a fermenter culture, the soil bacterium S. coelicolor undergoes a major metabolic switch from exponential growth to antibiotic production. We have studied gene expression patterns during this switch, using a specifically designed Affymetrix genechip and a high-resolution time-series of fermenter-grown samples.

Item Type: Journal Article
Subjects: Q Science > QR Microbiology
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Faculty of Science, Engineering and Medicine > Science > Statistics
Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Streptomyces coelicolor -- Genetic aspects, Antibiotic-producing organisms -- Genetics
Journal or Publication Title: BMC Genomics
Publisher: BioMed Central Ltd.
ISSN: 1471-2164
Official Date: 6 January 2010
Dates:
DateEvent
6 January 2010Published
6 January 2010Accepted
28 May 2009Submitted
Volume: 11
Page Range: p. 10
DOI: DOI: 10.1186/1471-2164-11-10
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Funder: European Research Area Network (ERA-NET), Norges forskningsråd [Research Council of Norway] (NF)
Grant number: SySMO Project [GEN2006- 27745-E/SYS]: (P-UK-01-11-3), Project no. 181840/I30] (NF)

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