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Prioritizing orphan proteins for further study using phylogenomics and gene expression profiles in Streptomyces coelicolor
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Alam, Mohammad Tauqee, Takano, Eriko and Breitling, Rainer (2011) Prioritizing orphan proteins for further study using phylogenomics and gene expression profiles in Streptomyces coelicolor. BMC Research Notes, 4 . p. 325. doi:10.1186/1756-0500-4-325 ISSN 1756-0500.
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Official URL: http://dx.doi.org/10.1186/1756-0500-4-325
Abstract
Streptomyces coelicolor, a model organism of antibiotic producing bacteria, has one of the largest genomes of the bacterial kingdom, including 7825 predicted protein coding genes. A large number of these genes, nearly 34%, are functionally orphan (hypothetical proteins with unknown function). However, in gene expression time course data, many of these functionally orphan genes show interesting expression patterns.
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