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Prioritizing orphan proteins for further study using phylogenomics and gene expression profiles in Streptomyces coelicolor

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Alam, Mohammad Tauqee, Takano, Eriko and Breitling, Rainer (2011) Prioritizing orphan proteins for further study using phylogenomics and gene expression profiles in Streptomyces coelicolor. BMC Research Notes, 4 . p. 325. doi:10.1186/1756-0500-4-325 ISSN 1756-0500.

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Official URL: http://dx.doi.org/10.1186/1756-0500-4-325

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Abstract

Streptomyces coelicolor, a model organism of antibiotic producing bacteria, has one of the largest genomes of the bacterial kingdom, including 7825 predicted protein coding genes. A large number of these genes, nearly 34%, are functionally orphan (hypothetical proteins with unknown function). However, in gene expression time course data, many of these functionally orphan genes show interesting expression patterns.

Item Type: Journal Article
Subjects: Q Science > QH Natural history
Q Science > QR Microbiology
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Microbiology & Infection
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Streptomyces coelicolor -- Genetic aspects
Journal or Publication Title: BMC Research Notes
Publisher: BioMed Central Ltd.
ISSN: 1756-0500
Official Date: 7 September 2011
Dates:
DateEvent
7 September 2011Published
7 September 2011Accepted
30 May 2011Submitted
Volume: 4
Page Range: p. 325
DOI: 10.1186/1756-0500-4-325
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Funder: Groningen Biomolecular Sciences and Biotechnology Institute (GBB), Rijksuniversiteit te Groningen [University of Groningen], Nederlandse Organisatie voor Wetenschappelijk Onderzoek [Netherlands Organisation for Scientific Research] (NWO)

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