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Neonatal predictors of cognitive ability in adults born very preterm : a prospective cohort study
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Breeman, Linda D., Jaekel, Julia, Baumann, Nicole, Bartmann, Peter and Wolke, Dieter (2017) Neonatal predictors of cognitive ability in adults born very preterm : a prospective cohort study. Developmental Medicine & Child Neurology, 59 (5). pp. 477-483. doi:10.1111/dmcn.13380 ISSN 0012-1622.
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Official URL: http://dx.doi.org/10.1111/dmcn.13380
Abstract
Aim:
To identify neonatal predictors to allow a developmental prognosis of the cognitive abilities of survivors born very preterm/very low birthweight (VLBW) into adult life.
Method:
The Bavarian Longitudinal Study is a prospective whole-population study that followed 260 infants born very preterm/VLBW from birth to adulthood. Regression analyses examined which neonatal factors predicted adult IQ.
Results:
Neonatal morbidity, neonatal treatment, and early social environment of infants born very preterm/VLBW explained 37.6% of the variance in adult IQ. Seven unique early-life predictors of lower adulthood IQ were found: respiratory distress syndrome, intraventricular haemorrhage, problems with mobility, mechanical ventilation, less parenteral nutrition, low/middle socioeconomic status, and poor early parent–infant relationships. Specifically, modifiable factors such as mechanical ventilation predicted a drop of 0.43 IQ points for each day of treatment, adjusted for initial respiratory problems. Good early parent–infant relationships predicted an approximately 5-point increase in adult IQ, adjusted for other significant predictors such as socioeconomic status.
Interpretation:
Mechanical ventilation, parenteral feeding, and early parenting were identified as significant modifiable factors that were strongly related to adult IQ. Mechanical ventilation policies have changed but there is scope for early interventions that focus on positive parenting, which may reduce the adverse effects of very preterm/VLBW birth on cognitive abilities.
Item Type: | Journal Article | ||||||||
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Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Science > Psychology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Premature infants, Birth weight, Low, Child development, Intelligence levels | ||||||||
Journal or Publication Title: | Developmental Medicine & Child Neurology | ||||||||
Publisher: | Wiley-Blackwell Publishing Ltd. | ||||||||
ISSN: | 0012-1622 | ||||||||
Official Date: | May 2017 | ||||||||
Dates: |
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Volume: | 59 | ||||||||
Number: | 5 | ||||||||
Page Range: | pp. 477-483 | ||||||||
DOI: | 10.1111/dmcn.13380 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 6 March 2017 | ||||||||
Date of first compliant Open Access: | 23 January 2018 | ||||||||
Funder: | Germany. Bundesministerium für Bildung und Forschung (BMBF) | ||||||||
Grant number: | PKE24, JUG14, 01EP9504 and 01ER0801 | ||||||||
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