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Mechanistic insights into class B radical-S-adenosylmethionine methylases : ubiquitous tailoring enzymes in natural product biosynthesis
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Zhou, Shanshan, Alkhalaf, Lona M., Emmanuel de los Santos, L. C. and Challis, Gregory L. (2016) Mechanistic insights into class B radical-S-adenosylmethionine methylases : ubiquitous tailoring enzymes in natural product biosynthesis. Current Opinion in Chemical Biology, 35 . pp. 73-79. doi:10.1016/j.cbpa.2016.08.021 ISSN 1367-5931.
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Official URL: http://dx.doi.org/10.1016/j.cbpa.2016.08.021
Abstract
Class B radical S-adenosylmethionine (SAM) methylases are notable for their ability to catalyse methylation reactions in the biosynthesis of a wide variety of natural products, including polyketides, ribosomally biosynthesised and post-translationally modified peptides (RiPPs), nonribosomal peptides (NRPs), aminoglycosides, β-lactams, phosphonates, enediynes, aminocoumarins and terpenes. Here, we discuss the diversity of substrates and catalytic mechanism utilised by such enzymes, highlighting the stereochemical course of methylation reactions at un-activated carbon centres and the ability of some members of the family to catalyse multiple methylations.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
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Journal or Publication Title: | Current Opinion in Chemical Biology | ||||||||
Publisher: | Elsevier Ltd. | ||||||||
ISSN: | 1367-5931 | ||||||||
Official Date: | December 2016 | ||||||||
Dates: |
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Volume: | 35 | ||||||||
Page Range: | pp. 73-79 | ||||||||
DOI: | 10.1016/j.cbpa.2016.08.021 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
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