Zhou, Shanshan, Alkhalaf, Lona M., Emmanuel de los Santos, L. C. and Challis, Gregory L. (2016) Mechanistic insights into class B radical-S-adenosylmethionine methylases : ubiquitous tailoring enzymes in natural product biosynthesis. Current Opinion in Chemical Biology, 35 . pp. 73-79. doi:10.1016/j.cbpa.2016.08.021 ISSN 1367-5931.

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Abstract

Class B radical S-adenosylmethionine (SAM) methylases are notable for their ability to catalyse methylation reactions in the biosynthesis of a wide variety of natural products, including polyketides, ribosomally biosynthesised and post-translationally modified peptides (RiPPs), nonribosomal peptides (NRPs), aminoglycosides, β-lactams, phosphonates, enediynes, aminocoumarins and terpenes. Here, we discuss the diversity of substrates and catalytic mechanism utilised by such enzymes, highlighting the stereochemical course of methylation reactions at un-activated carbon centres and the ability of some members of the family to catalyse multiple methylations.

Item Type:	Journal Article
Divisions:	Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Journal or Publication Title:	Current Opinion in Chemical Biology
Publisher:	Elsevier Ltd.
ISSN:	1367-5931
Official Date:	December 2016
Dates:	Date Event December 2016 Published 12 September 2016 Available UNSPECIFIED Accepted
Volume:	35
Page Range:	pp. 73-79
DOI:	10.1016/j.cbpa.2016.08.021
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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