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Separate neural systems for behavioral change and for emotional responses to failure during behavioral inhibition
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(2017) Separate neural systems for behavioral change and for emotional responses to failure during behavioral inhibition. Human Brain Mapping, 38 (7). pp. 3527-3537. ISSN 1065-9471.
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WRAP-Separate-neural-systems-behavioral-changed-Rolls-2017.pdf - Accepted Version - Requires a PDF viewer. Download (753Kb) | Preview |
Official URL: https://doi.org/10.1002/hbm.23607
Abstract
To analyze the involvement of different brain regions in behavioral inhibition and impulsiveness, differences in activation were investigated in fMRI data from a response inhibition task, the stop-signal task, in 1709 participants. First, areas activated more in stop-success than stop-failure included the lateral orbitofrontal cortex extending into the inferior frontal gyrus (ventrolateral prefrontal cortex, BA 47/12), and the dorsolateral prefrontal cortex. Second, the anterior cingulate and anterior insula were activated more on failure trials, specifically in stop-failure vs stop-success. The interaction between brain region and stop-success vs stop-failure activations was significant (p = 5.6 * 10-8). The results provide new evidence from this ‘big data’ investigation consistent with the hypotheses that the lateral orbitofrontal cortex is involved in the stop-related processing that inhibits the action; that the dorsolateral prefrontal cortex is involved in attentional processes that influence task performance; and that the anterior insula and anterior cingulate are involved in emotional processes when failure occurs. The investigation thus emphasizes the role of the human lateral orbitofrontal cortex BA 47/12 in changing behavior, and inhibiting behavior when necessary. A very similar area in BA47/12 is involved in changing behavior when an expected reward is not obtained, and has been shown to have high functional connectivity in depression.
| Item Type: | Journal Article | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Subjects: | B Philosophy. Psychology. Religion > BF Psychology Q Science > QP Physiology R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Brain mapping, Prefrontal cortex -- Physiology, Behavior modification, Computational neuroscience | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Journal or Publication Title: | Human Brain Mapping | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Publisher: | John Wiley and Sons | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ISSN: | 1065-9471 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Official Date: | July 2017 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Dates: |
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| Volume: | 38 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number: | 7 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Page Range: | pp. 3527-3537 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Date of first compliant deposit: | 10 April 2017 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Date of first compliant Open Access: | 21 April 2018 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Funder: | Royal Society (Great Britain). Wolfson Research Merit Award (RSWRMA), Guo jia zi ran ke xue ji jin wei yuan hui (China) [National Natural Science Foundation of China] (NSFC), Zhongguo ke xue yuan [Chinese Academy of Sciences] (CAS), Sixth Framework Programme (European Commission) (FP6), Seventh Framework Programme (European Commission) (FP7), Innovative Medicines Initiative (IMI), Medical Research Council (Great Britain) (MRC), Sweden. Vetenskapsrådet [Research Council], Wellcome Trust (London, England), National Institute for Health Research (Great Britain) (NIHR), Maudsley NHS Foundation Trust, King’s College London, Germany. Bundesministerium für Bildung und Forschung (BMBF), Deutsche Forschungsgemeinschaft (DFG), France. Agence nationale de la recherche (ANR), Fondation de France (FF), Fondation pour la recherche médicale (FRM), France. Mission interministérielle de lutte contre les drogues et les conduites addictives, Hôpitaux de Paris, Institut national de la santé et de la recherche médicale (France) (INSERM), Université Paris-Sud, National Institutes of Health (U.S.) (NIH) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Grant number: | 91230201 (NSFC), 2015AA02050 (CAS), 11101429 (NSFC), 11471081(NSFC), LSHM-CT-2007-037286 (FP6), 602450 (FP7), 602805 (FP7), 603016 (FP7), 115300-2 (IMI), 93558 (MRC), MR/N000390/1(MRC), 01GS08152 (BMBF); 01EV0711 (BMBF); eMED SysAlc01ZX1311A (BMBF), | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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